Engagement of Foxh1 in Chromatin Regulation Revealed by Protein Interactome Analyses

Overview

Journal Dev Growth Differ

Specialties Biology
Reproductive Medicine

Date 2022 Jul 18

PMID 35848281

Authors

Jeff Jiajing Zhou

Paula Duyen Pham

Han Han

Wenqi Wang

Ken W Y Cho

Affiliations

Soon will be listed here.

Abstract

Early embryonic cell fates are specified through coordinated integration of transcription factor activities and epigenetic states of the genome. Foxh1 is a key maternal transcription factor controlling the mesendodermal gene regulatory program. Proteomic interactome analyses using FOXH1 as a bait in mouse embryonic stem cells revealed that FOXH1 interacts with PRC2 subunits and HDAC1. Foxh1 physically interacts with Hdac1, and confers transcriptional repression of mesendodermal genes in Xenopus ectoderm. Our findings reveal a central role of Foxh1 in coordinating the chromatin states of the Xenopus embryonic genome.

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