Fast Synthesis of Graphene Oxide-β-Lactam As a Residue-Free Environmental Bacterial Inhibitor

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2022 Jul 18

PMID 35847294

Authors

Chenyan Hu

Pengfei Heng

Yuanyuan Zeng

Qing Zhang

Meilian Zhao

Zhongzhu Yang

Yang He

Affiliations

Soon will be listed here.

Abstract

Common pathogenic bacteria contaminate the environment through various modes of transmission. It is thus crucial to develop simple preparation methods of residue-free environmental disinfectants. β-Lactam antibiotics are frequently prescribed in clinical practice to treat bacterial infections. In this study, we used electrochemical exfoliation to synthesize graphene oxide (GO) with abundant ketene functional groups. A residue-free GO-β-lactam (GOβL) was subsequently obtained by mixing ketene and azomethine-H via a [2 + 2] cycloaddition reaction in the aqueous phase. GOβL has shown broad-spectrum bacterial inhibition against four bacteria (, , , and ), and it degrades rapidly within 24 h. This study provides a fast and easy method for the synthesis of GOβL, which can be employed as a promising environmental bacteriostatic disinfectant in real-life applications.

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