Effect of Oral Tranexamic Acid on the Blood Transfusion Rate and the Incidence of Deep Vein Thromboembolism in Patients After TKA

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2022 Jul 18

PMID 35845590

Authors

Bingqian Chen

Xiaohong Qu

Xiaowen Fang

Xuesong Wang

Guoxiu Ke

Affiliations

Soon will be listed here.

Abstract

Purpose: To explore the effect of oral tranexamic acid treatment on the blood transfusion rate and the incidence of deep vein thromboembolism after total knee arthroplasty (TKA).

Methods: 90 patients undergoing TKA admitted to First People's Hospital of Changshu City from January 2019 to January 2020 were selected and randomized into the control group and the experimental group accordingly (45 cases in each group). The control group intravenously received 20 mL/kg tranexamic acid before the incision was closed. The experimental group was given 1 g of tranexamic acid orally before anesthesia, 6 h and 12 h after the operation.

Results: The experimental group witnessed better perioperative indexes in relation to the control group. The experimental group displayed better postoperative coagulation function indexes as compared to the control group ( < 0.05). Remarkably lower postoperative vascular endothelial function indexes in the experimental group than in the control group were observed. The experimental group experienced a markedly lower incidence of deep vein thromboembolism in comparison with the control group ( < 0.05). The postoperative knee society score (KSS) score of the experimental group was significantly higher than that of the control group. A significantly higher postoperative modified rivermead mobility index (MRMI) score was yielded in the experimental group in contrast to the control group ( < 0.05). The experimental group obtained lower numerical rating scale (NRS) scores at T2 and T3 as compared to the control group.

Conclusion: Oral tranexamic acid is a suitable alternative for patients undergoing TKA in terms of reducing the blood transfusion rate, relieving pain, and accelerating the recovery of the patient's limbs.

Citing Articles

Retracted: Effect of Oral Tranexamic Acid on the Blood Transfusion Rate and the Incidence of Deep Vein Thromboembolism in Patients after TKA.

And Alternative Medicine E Evid Based Complement Alternat Med. 2023; 2023:9817504.

PMID: 37387880 PMC: 10307223. DOI: 10.1155/2023/9817504.

References

Kamal F, Khan M, Lee-Smith W, Sharma S, Imam Z, Jowhar D . Efficacy and safety of tranexamic acid in acute upper gastrointestinal bleeding: meta-analysis of randomised controlled trials. Scand J Gastroenterol. 2020; 55(12):1390-1397. DOI: 10.1080/00365521.2020.1839963. View

Castellarin G, Cimino V . A simple technique to perform total knee replacement without violating the femoral canal: early clinical results on a cohort of 303 patients. Eur J Orthop Surg Traumatol. 2020; 30(8):1377-1382. DOI: 10.1007/s00590-020-02711-5. View

Martin N, Padmanabhan V, Pindis J . Efficacy of Periarticular Cocktail Injection in Rheumatoid Patients Undergoing Total Knee Replacement. Indian J Orthop. 2020; 54(6):811-822. PMC: 7572924. DOI: 10.1007/s43465-020-00230-3. View

Hunt L, Blom A, Matharu G, Kunutsor S, Beswick A, Wilkinson J . Patients Receiving a Primary Unicompartmental Knee Replacement Have a Higher Risk of Revision but a Lower Risk of Mortality Than Predicted Had They Received a Total Knee Replacement: Data From the National Joint Registry for England, Wales, Northern.... J Arthroplasty. 2020; 36(2):471-477.e6. DOI: 10.1016/j.arth.2020.08.063. View

Smith S, Alvand A, Locock L, Ryan S, Smith J, Bayliss L . Partial or total knee replacement? Identifying patients' information needs on knee replacement surgery: a qualitative study to inform a decision aid. Qual Life Res. 2019; 29(4):999-1011. PMC: 7142054. DOI: 10.1007/s11136-019-02381-9. View

Ramaskandhan J, Rashid A, Kometa S, Siddique M . Comparison of 5-Year Patient-Reported Outcomes (PROMs) of Total Ankle Replacement (TAR) to Total Knee Replacement (TKR) and Total Hip Replacement (THR). Foot Ankle Int. 2020; 41(7):767-774. DOI: 10.1177/1071100720918880. View

Wainwright T, Gill M, McDonald D, Middleton R, Reed M, Sahota O . Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS) Society recommendations. Acta Orthop. 2019; 91(1):3-19. PMC: 7006728. DOI: 10.1080/17453674.2019.1683790. View

Beard D, Davies L, Cook J, MacLennan G, Price A, Kent S . Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT. Health Technol Assess. 2020; 24(20):1-98. PMC: 7232134. DOI: 10.3310/hta24200. View

Lam H, Tang Y, Wong H, Yang I . Similar early functional recovery after total knee replacement comparing single shot versus continuous saphenous nerve block: A randomised, double-blind trial. J Orthop Surg (Hong Kong). 2020; 28(2):2309499020932037. DOI: 10.1177/2309499020932037. View

10.

Jorgensen S, Bohn M, Aagaard P, Mechlenburg I . Efficacy of low-load blood flow restricted resistance EXercise in patients with Knee osteoarthritis scheduled for total knee replacement (EXKnee): protocol for a multicentre randomised controlled trial. BMJ Open. 2020; 10(10):e034376. PMC: 7534706. DOI: 10.1136/bmjopen-2019-034376. View

11.

Neginhal V, Kurtz W, Schroeder L . Patient Satisfaction, Functional Outcomes, and Survivorship in Patients with a Customized Posterior-Stabilized Total Knee Replacement. JBJS Rev. 2020; 8(7):e1900104. DOI: 10.2106/JBJS.RVW.19.00104. View

12.

Tu Y, Ma T, Wen T, Yang T, Xue L, Xue H . Does Unicompartmental Knee Replacement Offer Improved Clinical Advantages Over Total Knee Replacement in the Treatment of Isolated Lateral Osteoarthritis? A Matched Cohort Analysis From an Independent Center. J Arthroplasty. 2020; 35(8):2016-2021. DOI: 10.1016/j.arth.2020.03.021. View

13.

Gafter-Gvili A, Drozdinsky G, Zusman O, Kushnir S, Leibovici L . Venous Thromboembolism Prophylaxis in Acute Medically Ill Patients: A Retrospective Cohort Study. Am J Med. 2020; 133(12):1444-1452.e3. DOI: 10.1016/j.amjmed.2020.04.026. View

14.

Liao C, Tsauo J, Chiu Y, Ku J, Huang S, Liou T . Effects of Elastic Resistance Exercise After Total Knee Replacement on Muscle Mass and Physical Function in Elderly Women With Osteoarthritis: A Randomized Controlled Trial. Am J Phys Med Rehabil. 2019; 99(5):381-389. DOI: 10.1097/PHM.0000000000001344. View

15.

Ainle F, Kevane B . Which patients are at high risk of recurrent venous thromboembolism (deep vein thrombosis and pulmonary embolism)?. Hematology Am Soc Hematol Educ Program. 2020; 2020(1):201-212. PMC: 7727525. DOI: 10.1182/hematology.2020002268. View

16.

Ye Z, Zhu W, Xi X, Wu Q . The efficacy of bidirectional barbed sutures for incision closure in total knee replacement: A protocol of randomized controlled trial. Medicine (Baltimore). 2020; 99(34):e21867. PMC: 7447360. DOI: 10.1097/MD.0000000000021867. View

17.

Torres-Claramunt R, Gil-Gonzalez S, Hinarejos-Gomez P, Leal J, Sanchez-Soler J, Monllau-Garcia J . [Functional and quality of life results after a total knee replacement per year and five years of follow-up]. Acta Ortop Mex. 2021; 34(4):211-214. View

18.

Dominguez-Navarro F, Silvestre-Munoz A, Igual-Camacho C, Diaz-Diaz B, Torrella J, Rodrigo J . A randomized controlled trial assessing the effects of preoperative strengthening plus balance training on balance and functional outcome up to 1 year following total knee replacement. Knee Surg Sports Traumatol Arthrosc. 2020; 29(3):838-848. DOI: 10.1007/s00167-020-06029-x. View

19.

Alghadir A, Iqbal Z, Anwer S, Anwar D . Comparison of simultaneous bilateral versus unilateral total knee replacement on pain levels and functional recovery. BMC Musculoskelet Disord. 2020; 21(1):246. PMC: 7161292. DOI: 10.1186/s12891-020-03269-3. View

20.

Caliskan E, Igdir V, Dogan O, Bicimoglu A . Primary total knee replacement leads to an increase in physical activity but no changes in overall time of sedentary behaviour: a retrospective cohort study using an accelerometer. Int Orthop. 2020; 44(12):2597-2602. DOI: 10.1007/s00264-020-04720-9. View