Hereditary Angioedema and Thyroid Autoimmunity

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1987 May 1

PMID 3584502

Citations 10

Authors

M F Muhlemann

K D MacRae

A M Smith

P Beck

I Hine

U Hegde

G D Carter

P H Wise

J J Cream

Affiliations

Soon will be listed here.

Abstract

Sera from 91 patients with hereditary angioedema were screened for thyroid antibodies. The results for the 77 patients more than 17 years old were compared with previously published data for the prevalence of thyroid disease in a large community (Whickham). Of the female patients with hereditary angioedema, the prevalence of thyroglobulin antibodies (TGA) was 14.0%, higher than the expected 3% (p less than 0.001). The prevalence of thyroid microsomal antibodies (TMA) was 20%, also higher than the expected 7.6% (p less than 0.01). The age distributions of the females in both groups differed: in the group with hereditary angioedema there was a greater proportion of younger patients which should have resulted in a lower prevalence of thyroid antibodies. Adjusting for related patients with hereditary angioedema, there was still an increased prevalence of TGA (p less than 0.01) and TMA (p less than 0.01).

Citing Articles

Angioedema with Three Possible Etiologies.

Hall C, Petrie D, Crowley J, Sandall J, Newton F Kans J Med. 2022; 15:358-359.

PMID: 36196108 PMC: 9518713. DOI: 10.17161/kjm.vol15.16653.

Comorbidities in hereditary angioedema-A population-based cohort study.

Sundler Bjorkman L, Persson B, Aronsson D, Skattum L, Nordenfelt P, Egesten A Clin Transl Allergy. 2022; 12(3):e12135.

PMID: 35344299 PMC: 8967273. DOI: 10.1002/clt2.12135.

Malignancy and immune disorders in patients with hereditary angioedema.

Stepaniuk P, Kanani A Allergy Asthma Clin Immunol. 2021; 17(1):134.

PMID: 34924008 PMC: 8684618. DOI: 10.1186/s13223-021-00621-7.

Heat-Inactivation of Human Serum Destroys C1 Inhibitor, Pro-motes Immune Complex Formation, and Improves Human T Cell Function.

Fante M, Decking S, Bruss C, Schreml S, Siska P, Kreutz M Int J Mol Sci. 2021; 22(5).

PMID: 33808005 PMC: 7961502. DOI: 10.3390/ijms22052646.

Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review.

Levy D, Craig T, Keith P, Krishnarajah G, Beckerman R, Prusty S Allergy Asthma Clin Immunol. 2020; 16:41.

PMID: 32514272 PMC: 7254644. DOI: 10.1186/s13223-020-00437-x.

References

Pickering R, MICHAEL Jr A, Herdman R, GOOD R, Gewurz H . The complement system in chronic glomerulonephritis: three newly associated aberrations. J Pediatr. 1971; 78(1):30-43. DOI: 10.1016/s0022-3476(71)80261-5. View

Hall R, Dingle P, Roberts D . Thyroid antibodies: a study of first degree relatives. Clin Genet. 1972; 3(5):319-24. DOI: 10.1111/j.1399-0004.1972.tb01463.x. View

Kohler P, Percy J, CAMPION W, SMYTH C . Hereditary angioedema and "familial" lupus erythematosus in identical twin boys. Am J Med. 1974; 56(3):406-11. DOI: 10.1016/0002-9343(74)90623-8. View

DONALDSON V, Hess E, McADAMS A . Lupus-erythematosus-like disease in three unrelated women with hereditary angioneurotic edema. Ann Intern Med. 1977; 86(3):312-3. DOI: 10.7326/0003-4819-86-3-312. View

Tuffanelli D . Discoid lupus erythematosus and the variant form of hereditary angioedema. Arch Dermatol. 1977; 113(3):374-5. DOI: 10.1001/archderm.1977.01640030120024. View

Plaza J, Malasit P, Kerr D . Hereditary angio-oedema with mesangiocapillary glomerulonephritis. Postgrad Med J. 1977; 53(624):627-30. PMC: 2496760. DOI: 10.1136/pgmj.53.624.627. View

Tunbridge W, Evered D, Hall R, Appleton D, Brewis M, Clark F . The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf). 1977; 7(6):481-93. DOI: 10.1111/j.1365-2265.1977.tb01340.x. View

Seignalet C, Berthoux F, SEIGNALET J, Michel F . Hereditary angio-oedema and C3 nephritic factor--HL-A study. Clin Allergy. 1979; 9(5):527-33. DOI: 10.1111/j.1365-2222.1979.tb02517.x. View

Robson E, LACHMANN P, Hobart M, Johnston A . Linkage studies in hereditary angio-oedema. J Med Genet. 1979; 16(5):347-50. PMC: 1012607. DOI: 10.1136/jmg.16.5.347. View

10.

Young D, Thompson R, Mackie P . Plasmapheresis in hereditary angioneurotic edema and systemic lupus erythematosus. Arch Intern Med. 1980; 140(1):127-8. View

11.

Hory B, PANOUSE-PERRIN J, Suzuki Y, Faivre R, Saint-Hillier Y, Coulon G . [Immune complex nephropathy and hereditary deficiency of C1 esterase inhibitor (author's transl)]. Nouv Presse Med. 1981; 10(26):2193-6. View

12.

Massa M, Connolly S . An association between C1 esterase inhibitor deficiency and lupus erythematosus: report of two cases and review of the literature. J Am Acad Dermatol. 1982; 7(2):255-64. DOI: 10.1016/s0190-9622(82)70115-x. View

13.

LACHMANN P . Inherited complement deficiencies. Philos Trans R Soc Lond B Biol Sci. 1984; 306(1129):419-30. DOI: 10.1098/rstb.1984.0102. View