HP-NAP of : The Power of the Immunomodulation

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jul 18

PMID 35844568

Authors

Gaia Codolo

Sara Coletta

Mario Milco DElios

Marina de Bernard

Affiliations

Soon will be listed here.

Abstract

The miniferritin HP-NAP of was originally described as a neutrophil-activating protein because of the capacity to activate neutrophils to generate oxygen radicals and adhere to endothelia. Currently, the main feature for which HP-NAP is known is the ability to promote Th1 responses and revert the immune suppressive profile of macrophages. In this review, we discuss the immune modulating properties of the protein regarding the infection and the evidence that support the potential clinical application of HP-NAP in allergy and cancer immunotherapy.

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