Diabetes Mellitus Promotes the Development of Atherosclerosis: The Role of NLRP3

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jul 18

PMID 35844498

Authors

Jingxue Ye

Lanfang Li

Min Wang

Qiuxiao Ma

Yu Tian

Qiong Zhang

Jiushi Liu

Bin Li

Bengang Zhang

Haitao Liu

Guibo Sun

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is one of the main complications of diabetes mellitus, involving a variety of pathogenic factors. Endothelial dysfunction, inflammation, and oxidative stress are hallmarks of diabetes mellitus and atherosclerosis. Although the ability of diabetes to promote atherosclerosis has been demonstrated, a deeper understanding of the underlying biological mechanisms is critical to identifying new targets. NLRP3 plays an important role in both diabetes and atherosclerosis. While the diversity of its activation modes is one of the underlying causes of complex effects in the progression of diabetes and atherosclerosis, it also provides many new insights for targeted interventions in metabolic diseases.

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