An Adaptive Measure of Visuospatial Impairment in Dementia with Lewy Bodies

Overview

Journal Mov Disord Clin Pract

Publisher Wiley

Specialty Neurology

Date 2022 Jul 18

PMID 35844276

Authors

Joseph R Phillips

Elie Matar

Kaylena A Ehgoetz Martens

Ahmed A Moustafa

Glenda M Halliday

Simon J G Lewis

Affiliations

Soon will be listed here.

Abstract

Background: Dementia with Lewy bodies (DLB) is a common cause of dementia with poor prognosis and high hospitalization rates. DLB is frequently misdiagnosed, with clinical features that overlap significantly with other diseases including Parkinson's disease (PD). Clinical instruments that discriminate and track the progression of cognitive impairment in DLB are needed.

Objectives: The current study was designed to assess the utility of a mental rotation (MR) task for assessing visuospatial impairments in early DLB.

Methods: Accuracy of 22 DLB patients, 22 PD patients and 22 age-matched healthy controls in the MR task were compared at comparing shapes with 0°, 45° and 90° rotations.

Results: Healthy controls and PD patients performed at similar levels while the DLB group were significantly impaired. Further, impairment in the visuospatial and executive function measures correlated with MR poor outcomes.

Conclusion: These findings support the MR task as an objective measure of visuospatial impairment with the ability to adjust difficulty to suit impairments in a DLB population. This would be a useful tool within clinical trials.

Citing Articles

Evaluation of a cognition-sensitive spatial virtual reality game for Alzheimer's disease.

Chatterjee R, Moussavi Z Med Biol Eng Comput. 2024; .

PMID: 39725762 DOI: 10.1007/s11517-024-03270-1.

Visual dysfunction in dementia with Lewy bodies.

Devenyi R, Hamedani A Curr Neurol Neurosci Rep. 2024; 24(8):273-284.

PMID: 38907811 PMC: 11258179. DOI: 10.1007/s11910-024-01349-8.

Topological differences and confounders of mental rotation in cervical dystonia and blepharospasm.

Odorfer T, Yabe M, Hiew S, Volkmann J, Zeller D Sci Rep. 2023; 13(1):6026.

PMID: 37055560 PMC: 10102235. DOI: 10.1038/s41598-023-33262-4.

Exploring the Sensitivity of Prodromal Dementia with Lewy Bodies Research Criteria.

Phillips J, Matar E, Ehgoetz Martens K, Moustafa A, Halliday G, Lewis S Brain Sci. 2022; 12(12).

PMID: 36552054 PMC: 9775171. DOI: 10.3390/brainsci12121594.

References

Park K, Kim H, Cheon S, Cha J, Kim S, Kim J . Dementia with Lewy Bodies versus Alzheimer's Disease and Parkinson's Disease Dementia: A Comparison of Cognitive Profiles. J Clin Neurol. 2011; 7(1):19-24. PMC: 3079155. DOI: 10.3988/jcn.2011.7.1.19. View

Vann Jones S, OBrien J . The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychol Med. 2013; 44(4):673-83. DOI: 10.1017/S0033291713000494. View

Adduri C, Marotta J . Mental rotation of faces in healthy aging and Alzheimer's disease. PLoS One. 2009; 4(7):e6120. PMC: 2700266. DOI: 10.1371/journal.pone.0006120. View

Lineweaver T, Salmon D, Bondi M, Corey-Bloom J . Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation. J Int Neuropsychol Soc. 2005; 11(1):30-9. DOI: 10.1017/S1355617705050034. View

Prats-Sedano M, Savulich G, Surendranathan A, Donaghy P, Thomas A, Rowe J . The revised Addenbrooke's Cognitive Examination can facilitate differentiation of dementia with Lewy bodies from Alzheimer's disease. Int J Geriatr Psychiatry. 2020; 36(6):831-838. PMC: 8247047. DOI: 10.1002/gps.5483. View

McKeith I, Ferman T, Thomas A, Blanc F, Boeve B, Fujishiro H . Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology. 2020; 94(17):743-755. PMC: 7274845. DOI: 10.1212/WNL.0000000000009323. View

Ota K, Murayama N, Kasanuki K, Kondo D, Fujishiro H, Arai H . Visuoperceptual assessments for differentiating dementia with Lewy bodies and Alzheimer's disease: illusory contours and other neuropsychological examinations. Arch Clin Neuropsychol. 2015; 30(3):256-63. DOI: 10.1093/arclin/acv016. View

Shepard R, Metzler J . Mental rotation of three-dimensional objects. Science. 1971; 171(3972):701-3. DOI: 10.1126/science.171.3972.701. View

Aarsland D, Rongve A, Nore S, Skogseth R, Skulstad S, Ehrt U . Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria. Dement Geriatr Cogn Disord. 2008; 26(5):445-52. DOI: 10.1159/000165917. View

10.

Kane J, Surendranathan A, Bentley A, Barker S, Taylor J, Thomas A . Clinical prevalence of Lewy body dementia. Alzheimers Res Ther. 2018; 10(1):19. PMC: 5815202. DOI: 10.1186/s13195-018-0350-6. View

11.

Berneiser J, Jahn G, Grothe M, Lotze M . From visual to motor strategies: Training in mental rotation of hands. Neuroimage. 2016; 167:247-255. DOI: 10.1016/j.neuroimage.2016.06.014. View

12.

McKeith I, Boeve B, Dickson D, Halliday G, Taylor J, Weintraub D . Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017; 89(1):88-100. PMC: 5496518. DOI: 10.1212/WNL.0000000000004058. View

13.

Nagashima I, Takeda K, Shimoda N, Harada Y, Mochizuki H . Variation in Performance Strategies of a Hand Mental Rotation Task on Elderly. Front Hum Neurosci. 2019; 13:252. PMC: 6659582. DOI: 10.3389/fnhum.2019.00252. View

14.

Quental N, Brucki S, Bueno O . Visuospatial function in early Alzheimer's disease--the use of the Visual Object and Space Perception (VOSP) battery. PLoS One. 2013; 8(7):e68398. PMC: 3713013. DOI: 10.1371/journal.pone.0068398. View

15.

Pezzoli S, Cagnin A, Busse C, Zorzi G, Fragiacomo F, Bandmann O . Cognitive correlates and baseline predictors of future development of visual hallucinations in dementia with Lewy bodies. Cortex. 2021; 142:74-83. DOI: 10.1016/j.cortex.2021.05.018. View

16.

Calderon J, Perry R, Erzinclioglu S, Berrios G, Dening T, Hodges J . Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001; 70(2):157-64. PMC: 1737215. DOI: 10.1136/jnnp.70.2.157. View

17.

Zhao B, Della Sala S . Different representations and strategies in mental rotation. Q J Exp Psychol (Hove). 2017; 71(7):1574-1583. DOI: 10.1080/17470218.2017.1342670. View

18.

Bourrelier J, Kubicki A, Rouaud O, Crognier L, Mourey F . Mental Rotation as an Indicator of Motor Representation in Patients with Mild Cognitive Impairment. Front Aging Neurosci. 2016; 7:238. PMC: 4688352. DOI: 10.3389/fnagi.2015.00238. View

19.

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

20.

Bliwise D, Scullin M, Trotti L . Fluctuations in cognition and alertness vary independently in dementia with Lewy bodies. Mov Disord. 2013; 29(1):83-9. PMC: 3946909. DOI: 10.1002/mds.25707. View