Changes in Oral Function, Swallowing Function, and Quality of Life in Patients with Head and Neck Cancer: a Prospective Cohort Study

Overview

Journal BMC Oral Health

Publisher Biomed Central

Specialty Dentistry

Date 2022 Jul 17

PMID 35843950

Authors

Yoshiaki Ihara

Hirotaka Kato

Yuichi Tashimo

Yoshiki Iizumi

Yuma Fukunishi

Hitoshi Sato

Toshikazu Shimane

Koji Takahashi

Affiliations

Soon will be listed here.

Abstract

Background: Head and neck cancer (HNC) treatment can cause oral morbidities, such as oral dryness and dysphagia, affecting the patient's quality of life (QOL). The relationship between oral functions and QOL in patients with early-stage HNC remains poorly studied. This study aimed to evaluate changes in the QOL of patients with early-stage HNC and identify factors that affect the QOL of these patients.

Methods: In this prospective cohort study, 37 patients who underwent early-stage (Stage I/Stage II) HNC treatment were evaluated for their oral function, swallowing function, and the QOL score at baseline (BL) and 12 months after surgical treatment (12 M). The participants were divided into two groups: patients who returned to the BL QOL score at 12 M (RE; n = 26) and those who did not (NR; n = 11).

Results: In total, 29.7% (11/37) patients with early-stage HNC did not return to the BL QOL score at 12 M. There was no significant difference between the RE and NR groups regarding the oral and swallowing function. Moreover, oral and swallowing function of all patients returned to the BL at 12 M. The NR group showed lower QOL scores than the RE group in the global health status, and "sticky saliva" parameters in the questionnaires.

Conclusion: Restoration of the oral function is insufficient to improve the QOL of patients with early-stage HNC. The treatment of these patients should instead consider several factors that affect their QOL.

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References

de Araujo Gomes E, Fabio Aranha A, Borges A, Volpato L . Head and Neck Cancer Patients' Quality of Life: Analysis of Three Instruments. J Dent (Shiraz). 2020; 21(1):31-41. PMC: 7036356. DOI: 10.30476/DENTJODS.2019.77677.0. View

Crary M, Carnaby Mann G, Groher M . Initial psychometric assessment of a functional oral intake scale for dysphagia in stroke patients. Arch Phys Med Rehabil. 2005; 86(8):1516-20. DOI: 10.1016/j.apmr.2004.11.049. View

Yifru T, Kisa S, Dinegde N, Atnafu N . Dysphagia and its impact on the quality of life of head and neck cancer patients: institution-based cross-sectional study. BMC Res Notes. 2021; 14(1):11. PMC: 7791825. DOI: 10.1186/s13104-020-05440-4. View

Wada S, Tohara H, Iida T, Inoue M, Sato M, Ueda K . Jaw-opening exercise for insufficient opening of upper esophageal sphincter. Arch Phys Med Rehabil. 2012; 93(11):1995-9. DOI: 10.1016/j.apmr.2012.04.025. View

Rutten H, Pop L, Janssens G, Takes R, Knuijt S, Rooijakkers A . Long-term outcome and morbidity after treatment with accelerated radiotherapy and weekly cisplatin for locally advanced head-and-neck cancer: results of a multidisciplinary late morbidity clinic. Int J Radiat Oncol Biol Phys. 2010; 81(4):923-9. DOI: 10.1016/j.ijrobp.2010.07.013. View

Trivedi N, Swaminathan D, Thankappan K, Chatni S, Kuriakose M, Iyer S . Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiotherapy vs total laryngectomy. Otolaryngol Head Neck Surg. 2008; 139(5):702-7. DOI: 10.1016/j.otohns.2008.06.002. View

Gupta B, Johnson N, Kumar N . Global Epidemiology of Head and Neck Cancers: A Continuing Challenge. Oncology. 2016; 91(1):13-23. DOI: 10.1159/000446117. View

Luo J, Wu J, Lv K, Li K, Wu J, Wen Y . Analysis of Postsurgical Health-Related Quality of Life and Quality of Voice of Patients With Laryngeal Carcinoma. Medicine (Baltimore). 2016; 95(1):e2363. PMC: 4706258. DOI: 10.1097/MD.0000000000002363. View

Baijens L, Walshe M, Aaltonen L, Arens C, Cordier R, Cras P . European white paper: oropharyngeal dysphagia in head and neck cancer. Eur Arch Otorhinolaryngol. 2020; 278(2):577-616. PMC: 7826315. DOI: 10.1007/s00405-020-06507-5. View

10.

Ihara Y, Tashimo Y, Nozue S, Iizumi Y, Fukunishi Y, Saito Y . Changes in Oral Function and Quality of Life in Tongue Cancer Patients Based on Resected Area. Asian Pac J Cancer Prev. 2021; 22(8):2549-2557. PMC: 8629473. DOI: 10.31557/APJCP.2021.22.8.2549. View

11.

Greco E, Simic T, Ringash J, Tomlinson G, Inamoto Y, Martino R . Dysphagia Treatment for Patients With Head and Neck Cancer Undergoing Radiation Therapy: A Meta-analysis Review. Int J Radiat Oncol Biol Phys. 2018; 101(2):421-444. DOI: 10.1016/j.ijrobp.2018.01.097. View

12.

Iriya P, Romaniszen L, Fernandes T, Poleti M . Health-related quality of life of patients with squamous cell carcinoma: a comparison according to tumor location. Braz Oral Res. 2017; 31:e105. DOI: 10.1590/1807-3107BOR-2017.vol31.0105. View

13.

Zebralla V, Wichmann G, Pirlich M, Hammermuller C, Berger T, Zimmermann K . Dysphagia, voice problems, and pain in head and neck cancer patients. Eur Arch Otorhinolaryngol. 2021; 278(10):3985-3994. PMC: 8382612. DOI: 10.1007/s00405-020-06584-6. View

14.

Ganzer H, Rothpletz-Puglia P, Byham-Gray L, Murphy B, Touger-Decker R . The eating experience in long-term survivors of head and neck cancer: a mixed-methods study. Support Care Cancer. 2015; 23(11):3257-68. DOI: 10.1007/s00520-015-2730-9. View

15.

Ringash J . Quality of Life in Head and Neck Cancer: Where We Are, and Where We Are Going. Int J Radiat Oncol Biol Phys. 2017; 97(4):662-666. DOI: 10.1016/j.ijrobp.2016.12.033. View

16.

Ramaekers B, Joore M, Grutters J, van den Ende P, de Jong J, Houben R . The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy. Oral Oncol. 2011; 47(8):768-74. DOI: 10.1016/j.oraloncology.2011.05.012. View

17.

Ihara Y, Crary M, Madhavan A, Gregorio D, Im I, Ross S . Dysphagia and Oral Morbidities in Chemoradiation-Treated Head and Neck Cancer Patients. Dysphagia. 2018; 33(6):739-748. DOI: 10.1007/s00455-018-9895-6. View

18.

Kim D, Park H, Park S, Kim J . The impact of dysphagia on quality of life in stroke patients. Medicine (Baltimore). 2020; 99(34):e21795. PMC: 7447354. DOI: 10.1097/MD.0000000000021795. View

19.

Kalyanam B, Sarala N, Azeem Mohiyuddin S, Diwakar R . Auditory function and quality of life in patients receiving cisplatin chemotherapy in head and neck cancer: A case series follow-up study. J Cancer Res Ther. 2018; 14(5):1099-1104. DOI: 10.4103/0973-1482.188426. View

20.

Carnaby G, Crary M . Development and validation of a cancer-specific swallowing assessment tool: MASA-C. Support Care Cancer. 2013; 22(3):595-602. DOI: 10.1007/s00520-013-2011-4. View