The Repeatability of Corneal Topography Measurements in Severe Dry Eye Disease

Overview

Journal BMC Ophthalmol

Publisher Biomed Central

Specialty Ophthalmology

Date 2022 Jul 15

PMID 35840937

Authors

Soner Guven

Affiliations

Soon will be listed here.

Abstract

Background: To determine the repeatability of corneal topography measurements in severe dry eye disease (DED). A comparison of corneal topography parameters between severe DED and healthy subjects was a secondary goal of this study.

Methods: Sixty-nine patients with severe DED and 46 healthy subjects were enrolled in the study. All participants underwent repeated corneal topography measurements with Pentacam (Oculus, Germany) within a half hour time. Both eyes of the participants were used in statistical analysis. A further subcategorization of severe DED patients was performed according to Ocular Surface Disease Index (OSDI) scores: 32-50, 51-70 and 71-100. The repeatability of corneal parameters was assessed with correlation coefficients (CC).

Results: The mean age of dry eye patients and healthy subjects were 40.8 ± 13.2 (17-66) and 39.8 ± 8.2 (18-61) years (p:0.604) respectively. No significant differences were found between severe DED and control groups according to analysed corneal parameters in both eyes (p:>0.05). All CCs were greater than 0.9 in severe DED group (p:<0.001). All CCs were also greater than 0.9 in severe DED patients among different OSDI groups (p:<0.001).

Conclusions: Corneal topography measurements are highly repeatable in severe DED with Pentacam. This is the first report about this topic. Nonetheless, further studies are needed with different topography devices for validation.

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References

BarKana Y, Gerber Y, Elbaz U, Schwartz S, Ken-Dror G, Avni I . Central corneal thickness measurement with the Pentacam Scheimpflug system, optical low-coherence reflectometry pachymeter, and ultrasound pachymetry. J Cataract Refract Surg. 2005; 31(9):1729-35. DOI: 10.1016/j.jcrs.2005.03.058. View

Zemova E, Eppig T, Seitz B, Toropygin S, Arnold S, Langenbucher A . Interaction between topographic/tomographic parameters and dry eye disease in keratoconus patients. Curr Eye Res. 2013; 39(1):1-8. DOI: 10.3109/02713683.2013.798667. View

Fujisawa K, Sasaki K . Changes in light scattering intensity of the transparent lenses of subjects selected from population-based surveys depending on age: analysis through Scheimpflug images. Ophthalmic Res. 1995; 27(2):89-101. DOI: 10.1159/000267604. View

Lemp M . Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995; 21(4):221-32. View

Xu Z, Peng M, Jiang J, Yang C, Zhu W, Lu F . Reliability of Pentacam HR Thickness Maps of the Entire Cornea in Normal, Post-Laser In Situ Keratomileusis, and Keratoconus Eyes. Am J Ophthalmol. 2015; 162:74-82.e1. DOI: 10.1016/j.ajo.2015.11.008. View

Viso E, Rodriguez-Ares M, Abelenda D, Oubina B, Gude F . Prevalence of asymptomatic and symptomatic meibomian gland dysfunction in the general population of Spain. Invest Ophthalmol Vis Sci. 2012; 53(6):2601-6. DOI: 10.1167/iovs.11-9228. View

Zhuang H, Zhou X, Xu J . A novel method for pachymetry mapping of human precorneal tear film using Pentacam with fluorescein. Invest Ophthalmol Vis Sci. 2009; 51(1):156-9. DOI: 10.1167/iovs.08-3265. View

Lee J, Kim J, Kim S . Repeatability of Central Corneal Thickness Measurement Using Rotating Scheimpflug Camera in Dry and Normal Eyes. Eye Contact Lens. 2017; 44 Suppl 2:S29-S32. DOI: 10.1097/ICL.0000000000000373. View

Fujimoto K, Inomata T, Okumura Y, Iwata N, Fujio K, Eguchi A . Comparison of corneal thickness in patients with dry eye disease using the Pentacam rotating Scheimpflug camera and anterior segment optical coherence tomography. PLoS One. 2020; 15(2):e0228567. PMC: 6996840. DOI: 10.1371/journal.pone.0228567. View

10.

Wolffsohn J, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K . TFOS DEWS II Diagnostic Methodology report. Ocul Surf. 2017; 15(3):539-574. DOI: 10.1016/j.jtos.2017.05.001. View

11.

Meyer L, Kronschlager M, Wegener A . [Schleimpflug photography detects alterations in corneal density and thickness in patients with dry eye disease]. Ophthalmologe. 2014; 111(10):914-9. DOI: 10.1007/s00347-013-2964-1. View

12.

Craig J, Nichols K, Akpek E, Caffery B, Dua H, Joo C . TFOS DEWS II Definition and Classification Report. Ocul Surf. 2017; 15(3):276-283. DOI: 10.1016/j.jtos.2017.05.008. View

13.

Baudouin C, Aragona P, van Setten G, Rolando M, Irkec M, Benitez del Castillo J . Diagnosing the severity of dry eye: a clear and practical algorithm. Br J Ophthalmol. 2014; 98(9):1168-76. PMC: 4145432. DOI: 10.1136/bjophthalmol-2013-304619. View

14.

Stapleton F, Alves M, Bunya V, Jalbert I, Lekhanont K, Malet F . TFOS DEWS II Epidemiology Report. Ocul Surf. 2017; 15(3):334-365. DOI: 10.1016/j.jtos.2017.05.003. View

15.

Schiffman R, Christianson M, Jacobsen G, Hirsch J, Reis B . Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol. 2000; 118(5):615-21. DOI: 10.1001/archopht.118.5.615. View

16.

Dogan A, Gurdal C, Koylu M . Does Dry Eye Affect Repeatability of Corneal Topography Measurements?. Turk J Ophthalmol. 2018; 48(2):57-60. PMC: 5938476. DOI: 10.4274/tjo.10179. View

17.

Bron A, Evans V, Smith J . Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003; 22(7):640-50. DOI: 10.1097/00003226-200310000-00008. View