Alterations in Functional Connectivity and Interactions in Resting-state Networks in Female Patients with Functional Constipation

Overview

Journal Neurol Sci

Specialty Neurology

Date 2022 Jul 15

PMID 35840872

Authors

Lei Zhang

Guanya Li

Yang Hu

Wenchao Zhang

Jia Wang

Weibin Ji

Fukun Jiang

Yaqi Zhang

Feifei Wu

Karen M von Deneen

Shijun Duan

Guangbin Cui

Yi Zhang

Yongzhan Nie

Affiliations

Soon will be listed here.

Abstract

Methods: Functional MRI with independent component analysis was applied to investigate alterations in FC within and functional network connectivity (FNC) between RSNs including default mode- (DMN), basal ganglia- (BGN), salience- (SN), and left and right control executive-networks (LCEN/RCEN) in 39 female patients with FCon and 36 female healthy controls (HC). Patient Assessment of Constipation Quality of Life Scale (PAC-QOL) and Patient Assessment of Constipation Symptom Scale (PAC-SYM) were used to assess the constipation symptoms.

Results: FCon patients had changed regional FC between different networks contributing to the abnormal FNC among RSNs compared with HC. Patients with greater stool syndromes had increased FNC of BGN-SN and DMN-LCEN, and patients with greater worries/concerns and PAC-QOL total score had reduced FNC of SN-RCEN. The greater strength changes in FC in prefrontal and parietal cortices were associated with higher negative emotion scores and greater rectal symptoms, respectively.

Conclusion: The findings suggested that FCon patients had altered FC within and interactions between RSNs and the brain FC changes were associated with constipation symptoms and altered emotions.

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