Uric Acid and Cardiometabolic Risk by Gender in Youth with Type 1 Diabetes

Overview

Journal Sci Rep

Specialty Science

Date 2022 Jul 15

PMID 35840585

Authors

Procolo Di Bonito

Francesco Maria Rosanio

Maria Loredana Marcovecchio

Valentino Cherubini

Maurizio Delvecchio

Francesca Di Candia

Dario Iafusco

Angela Zanfardino

Brunella Iovane

Claudio Maffeis

Giulio Maltoni

Carlo Ripoli

Elvira Piccinno

Claudia Anita Piona

Maria Rossella Ricciardi

Riccardo Schiaffini

Adriana Franzese

Enza Mozzillo

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youth with type 1 diabetes (T1D). Retrospective data collected from 1323 children and adolescents (5-18 years; 716 boys) with T1D recruited in 9 Italian Pediatric Diabetes Centers were analyzed. CMRFs included UA, HbA, blood pressure (BP), cholesterol (TC), HDL, triglycerides (TG), neutrophils (N) and lymphocytes (L) count, glomerular filtration rate (eGFR) (calculated using Schwartz-Lyon equation). In boys, we found a higher age, daily insulin dose, TG, TG/HDL ratio, TC/HDL ratio, systolic BP, N/L ratio and lower HDL, and eGFR across UA tertiles (p = 0.01-0.0001). Similar results were found in girls but not for TG and systolic BP. In boys, the odds ratio (OR) of high levels of TG/HDL ratio, TC/HDL ratio, BP and mildly reduced eGFR (MRGFR) increased for 0.5 mg/dL of UA. Instead, in girls an increased levels of 0.5 mg/dL of UA were associated with high OR of TC/HDL ratio, N/L ratio and MRGFR. Uric acid may represent a useful marker for identifying youth with T1D at high cardiometabolic risk, and this association appears to vary by sex.

Citing Articles

Relationship between uric acid to HDL ratio and extent and severity of coronary artery disease.

Yaman M, Kilinc A, Ozturk F, Coskun M, Duz R, Gunes Y Postepy Kardiol Interwencyjnej. 2025; 20(4):401-405.

PMID: 39897005 PMC: 11783253. DOI: 10.5114/aic.2024.145034.

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