Effect of Maternal Pregestational Diabetes Mellitus on Congenital Heart Diseases

Overview

Journal World J Pediatr

Specialty Pediatrics

Date 2022 Jul 15

PMID 35838899

Authors

Zhi-Yan Chen

Shuang-Fa Mao

Ling-Hong Guo

Jian Qin

Li-Xin Yang

Yin Liu

Affiliations

Soon will be listed here.

Abstract

Background: The increasing population of diabetes mellitus in adolescent girls and women of childbearing age contributes to a large number of pregnancies with maternal pregestational diabetes mellitus. Congenital heart diseases are a common adverse outcome in mothers with pregestational diabetes mellitus. However, there is little systematic information between maternal pregestational diabetes mellitus and congenital heart diseases in the offspring.

Data Sources: Literature selection was performed in PubMed. One hundred and seven papers were cited in our review, including 36 clinical studies, 26 experimental studies, 31 reviews, eight meta-analysis articles, and six of other types.

Results: Maternal pregestational diabetes mellitus poses a high risk of congenital heart diseases in the offspring and causes variety of phenotypes of congenital heart diseases. Factors such as persistent maternal hyperglycemia, oxidative stress, polymorphism of uncoupling protein 2, polymorphism of adiponectin gene, Notch 1 pathway, Nkx2.5 disorders, dysregulation of the hypoxia-inducible factor 1, and viral etiologies are associated with the occurrence of congenital heart diseases in the offspring of mothers with pregestational diabetes mellitus. Treatment options including blood sugar-reducing, anti-oxidative stress drug supplements and exercise can help to prevent maternal pregestational diabetes mellitus from inducing congenital heart diseases.

Conclusions: Our review contributes to a better understanding of the association between maternal pregestational diabetes mellitus and congenital heart diseases in the offspring and to a profound thought of the mechanism, preventive and therapeutic measurements of congenital heart diseases caused by maternal pregestational diabetes mellitus.

Citing Articles

Association of congenital heart defects (CHD) with factors related to maternal health and pregnancy in newborns in Puerto Rico.

Delgado Y, Gaytan C, Perez N, Miranda E, Morales B, Santos M Congenit Heart Dis. 2024; 19(1):19-31.

PMID: 38912385 PMC: 11192526. DOI: 10.32604/chd.2024.046339.

Tergitol Based Decellularization Protocol Improves the Prerequisites for Pulmonary Xenografts: Characterization and Biocompatibility Assessment.

Tondato S, Moro A, Butt S, Todesco M, Sandrin D, Borile G Polymers (Basel). 2023; 15(4).

PMID: 36850103 PMC: 9967102. DOI: 10.3390/polym15040819.

References

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N . Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9 edition. Diabetes Res Clin Pract. 2019; 157:107843. DOI: 10.1016/j.diabres.2019.107843. View

Zimmet P, Magliano D, Herman W, Shaw J . Diabetes: a 21st century challenge. Lancet Diabetes Endocrinol. 2014; 2(1):56-64. DOI: 10.1016/S2213-8587(13)70112-8. View

Mayer-Davis E, Dabelea D, Lawrence J . Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012. N Engl J Med. 2017; 377(3):301. PMC: 5639715. DOI: 10.1056/NEJMc1706291. View

Menke A, Casagrande S, Cowie C . Contributions of A1c, fasting plasma glucose, and 2-hour plasma glucose to prediabetes prevalence: NHANES 2011-2014. Ann Epidemiol. 2018; 28(10):681-685.e2. DOI: 10.1016/j.annepidem.2018.07.012. View

Andes L, Cheng Y, Rolka D, Gregg E, Imperatore G . Prevalence of Prediabetes Among Adolescents and Young Adults in the United States, 2005-2016. JAMA Pediatr. 2019; 174(2):e194498. PMC: 6902249. DOI: 10.1001/jamapediatrics.2019.4498. View

Rughani A, Friedman J, Tryggestad J . Type 2 Diabetes in Youth: the Role of Early Life Exposures. Curr Diab Rep. 2020; 20(9):45. DOI: 10.1007/s11892-020-01328-6. View

Chivese T, Werfalli M, Magodoro I, Chinhoyi R, Kengne A, Norris S . Prevalence of type 2 diabetes mellitus in women of childbearing age in Africa during 2000-2016: a systematic review and meta-analysis. BMJ Open. 2019; 9(5):e024345. PMC: 6538083. DOI: 10.1136/bmjopen-2018-024345. View

Peters T, Brazeau A . Exercise in Pregnant Women with Diabetes. Curr Diab Rep. 2019; 19(9):80. DOI: 10.1007/s11892-019-1204-8. View

Rezai S, LoBue S, Henderson C . Diabetes prevention: Reproductive age women affected by insulin resistance. Womens Health (Lond). 2016; 12(4):427-32. PMC: 5373272. DOI: 10.1177/1745505716653691. View

10.

Arendt L, Pedersen L, Pedersen L, Ovesen P, Henriksen T, Lindhard M . Glycemic Control in Pregnancies Complicated by Pre-Existing Diabetes Mellitus and Congenital Malformations: A Danish Population-Based Study. Clin Epidemiol. 2021; 13:615-626. PMC: 8325058. DOI: 10.2147/CLEP.S298748. View

11.

Eidem I, Stene L, Henriksen T, Hanssen K, Vangen S, Vollset S . Congenital anomalies in newborns of women with type 1 diabetes: nationwide population-based study in Norway, 1999-2004. Acta Obstet Gynecol Scand. 2010; 89(11):1403-11. DOI: 10.3109/00016349.2010.518594. View

12.

Zegkos T, Ntiloudi D, Giannakoulas G . Parental alcohol exposure and congenital heart diseases in offspring: A causal link with controversial evidence. Eur J Prev Cardiol. 2019; 27(4):407-409. DOI: 10.1177/2047487319877705. View

13.

van der Linde D, Konings E, Slager M, Witsenburg M, Helbing W, Takkenberg J . Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011; 58(21):2241-7. DOI: 10.1016/j.jacc.2011.08.025. View

14.

Chen Z, Li S, Guo L, Peng X, Liu Y . Prenatal alcohol exposure induced congenital heart diseases: From bench to bedside. Birth Defects Res. 2020; 113(7):521-534. DOI: 10.1002/bdr2.1743. View

15.

Vincent F, Ternacle J, Denimal T, Shen M, Redfors B, Delhaye C . Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis. Circulation. 2021; 143(10):1043-1061. DOI: 10.1161/CIRCULATIONAHA.120.048048. View

16.

Engineer A, Saiyin T, Greco E, Feng Q . Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal Diabetes. Antioxidants (Basel). 2019; 8(10). PMC: 6826639. DOI: 10.3390/antiox8100436. View

17.

Faraoni D, Nasr V, DiNardo J . Overall Hospital Cost Estimates in Children with Congenital Heart Disease: Analysis of the 2012 Kid's Inpatient Database. Pediatr Cardiol. 2015; 37(1):37-43. DOI: 10.1007/s00246-015-1235-0. View

18.

Bhatt A, Foster E, Kuehl K, Alpert J, Brabeck S, Crumb S . Congenital heart disease in the older adult: a scientific statement from the American Heart Association. Circulation. 2015; 131(21):1884-931. DOI: 10.1161/CIR.0000000000000204. View

19.

Ntiloudi D, Zegkos T, Bazmpani M, Parcharidou D, Panagiotidis T, Hadjimiltiades S . Pregnancy outcome in women with congenital heart disease: A single-center experience. Hellenic J Cardiol. 2017; 59(3):155-159. DOI: 10.1016/j.hjc.2017.08.008. View

20.

Ntiloudi D, Zegkos T, Koutsakis A, Giannakoulas G, Karvounis H . Pregnancy in Patients With Congenital Heart Disease: A Contemporary Challenge. Cardiol Rev. 2017; 25(6):326-330. DOI: 10.1097/CRD.0000000000000160. View