Phenotypic and Genotypic Detection Methods for Antimicrobial Resistance in ESKAPE Pathogens (Review)

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2022 Jul 15

PMID 35837033

Authors

Madalina Maria Muntean

Andrei-Alexandru Muntean

Madalina Preda

Loredana Sabina Cornelia Manolescu

Cerasella Dragomirescu

Mircea-Ioan Popa

Gabriela Loredana Popa

Affiliations

Soon will be listed here.

Abstract

Antimicrobial resistance (AMR) represents a growing public health problem worldwide. Infections with such bacteria lead to longer hospitalization times, higher healthcare costs and greater morbidity and mortality. Thus, there is a greater need for rapid detection methods in order to limit their spread. The ESKAPE pathogens (, , , , and spp.) are a series of epidemiologically-important microorganisms of great concern due to their high levels of resistance. This review aimed to update the background information on the ESKAPE pathogens as well as to provide a summary of the numerous phenotypic and molecular methods used to detect their AMR mechanisms. While they are usually linked to hospital acquired infections, AMR is also spreading in the veterinary and the environmental sectors. Yet, the epidemiological loop closes with patients which, when infected with such pathogens, often lack therapeutic options. Thus, it was aimed to give the article a One Health perspective.

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