NF-kB (p50/p65)-Mediated Pro-Inflammatory MicroRNA (miRNA) Signaling in Alzheimer's Disease (AD)

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2022 Jul 15

PMID 35836546

Authors

Walter J Lukiw

Affiliations

Soon will be listed here.

Citing Articles

Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer's disease: a bioinformatics and experimental study.

Zhang S, Zhang R, Chen Z, Shao Z, Li A, Li F Front Aging Neurosci. 2025; 16():1511668.

PMID: 39872979 PMC: 11770030. DOI: 10.3389/fnagi.2024.1511668.

The crosstalk between neuropilin-1 and tumor necrosis factor-α in endothelial cells.

Wang Y, Wang E, Anany M, Fullsack S, Huo Y, Dutta S Front Cell Dev Biol. 2024; 12:1210944.

PMID: 38994453 PMC: 11236538. DOI: 10.3389/fcell.2024.1210944.

Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms.

Liu S, Chen W, Zhao Y, Zong Y, Li J, He Z Molecules. 2023; 28(23).

PMID: 38067664 PMC: 10708332. DOI: 10.3390/molecules28237935.

Endogenous miRNA-Based Innate-Immunity against SARS-CoV-2 Invasion of the Brain.

Lukiw W, Pogue A Int J Mol Sci. 2023; 24(4).

PMID: 36834773 PMC: 9966119. DOI: 10.3390/ijms24043363.

Lipopolysaccharides (LPSs) as Potent Neurotoxic Glycolipids in Alzheimer's Disease (AD).

Zhao Y, Jaber V, Pogue A, Sharfman N, Taylor C, Lukiw W Int J Mol Sci. 2022; 23(20).

PMID: 36293528 PMC: 9604166. DOI: 10.3390/ijms232012671.

References

Mirza F, Zahid S . The Role of Synapsins in Neurological Disorders. Neurosci Bull. 2017; 34(2):349-358. PMC: 5856722. DOI: 10.1007/s12264-017-0201-7. View

Uddin M, Hasana S, Ahmad J, Hossain M, Rahman M, Behl T . Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease. Curr Pharm Des. 2020; 27(3):402-414. DOI: 10.2174/1381612826666201118092422. View

Jauhari A, Singh T, Mishra S, Shankar J, Yadav S . Coordinated Action of miR-146a and Parkin Gene Regulate Rotenone-induced Neurodegeneration. Toxicol Sci. 2020; 176(2):433-445. DOI: 10.1093/toxsci/kfaa066. View

Gilmore T, Herscovitch M . Inhibitors of NF-kappaB signaling: 785 and counting. Oncogene. 2006; 25(51):6887-99. DOI: 10.1038/sj.onc.1209982. View

Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z . CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell. 2018; 9(11):945-965. PMC: 6208479. DOI: 10.1007/s13238-018-0560-5. View

Czapski G, Cieslik M, Bialopiotrowicz E, Lukiw W, Strosznajder J . Down-regulation of cyclin D2 in amyloid β toxicity, inflammation, and Alzheimer's disease. PLoS One. 2021; 16(11):e0259740. PMC: 8601534. DOI: 10.1371/journal.pone.0259740. View

Zhao Y, Sharfman N, Jaber V, Lukiw W . Down-Regulation of Essential Synaptic Components by GI-Tract Microbiome-Derived Lipopolysaccharide (LPS) in LPS-Treated Human Neuronal-Glial (HNG) Cells in Primary Culture: Relevance to Alzheimer's Disease (AD). Front Cell Neurosci. 2019; 13:314. PMC: 6635554. DOI: 10.3389/fncel.2019.00314. View

Lukiw W, Zhao Y, Cui J . An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem. 2008; 283(46):31315-22. PMC: 2581572. DOI: 10.1074/jbc.M805371200. View

Trejo-Lopez J, Yachnis A, Prokop S . Neuropathology of Alzheimer's Disease. Neurotherapeutics. 2021; 19(1):173-185. PMC: 9130398. DOI: 10.1007/s13311-021-01146-y. View

10.

Xu H, Zhang J, Shi X, Li X, Zheng C . NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome. Aging (Albany NY). 2021; 13(16):20774-20792. PMC: 8436920. DOI: 10.18632/aging.203466. View

11.

Bhattacharjee S, Zhao Y, Dua P, Rogaev E, Lukiw W . microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. PLoS One. 2016; 11(3):e0150211. PMC: 4780721. DOI: 10.1371/journal.pone.0150211. View

12.

Zhao Y, Arceneaux L, Culicchia F, Lukiw W . Neurofilament Light (NF-L) Chain Protein from a Highly Polymerized Structural Component of the Neuronal Cytoskeleton to a Neurodegenerative Disease Biomarker in the Periphery. HSOA J Alzheimers Neurodegener Dis. 2021; 7(2). PMC: 8651065. DOI: 10.24966/AND-9608/100056. View

13.

Liu S, Fan M, Zheng Q, Hao S, Yang L, Xia Q . MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets. Biomed Pharmacother. 2022; 148:112681. DOI: 10.1016/j.biopha.2022.112681. View

14.

Zhan X, Stamova B, Sharp F . Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer's Disease Brain: A Review. Front Aging Neurosci. 2018; 10:42. PMC: 5827158. DOI: 10.3389/fnagi.2018.00042. View

15.

Alexandrov P, Zhai Y, Li W, Lukiw W . Lipopolysaccharide-stimulated, NF-kB-, miRNA-146a- and miRNA-155-mediated molecular-genetic communication between the human gastrointestinal tract microbiome and the brain. Folia Neuropathol. 2019; 57(3):211-219. DOI: 10.5114/fn.2019.88449. View

16.

Chen M, Hong C, Yue T, Li H, Duan R, Hu W . Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy. Theranostics. 2021; 11(5):2395-2409. PMC: 7797673. DOI: 10.7150/thno.47408. View

17.

Jaber V, Zhao Y, Lukiw W . Alterations in micro RNA-messenger RNA (miRNA-mRNA) Coupled Signaling Networks in Sporadic Alzheimer's Disease (AD) Hippocampal CA1. J Alzheimers Dis Parkinsonism. 2017; 7(2). PMC: 5645033. DOI: 10.4172/2161-0460.1000312. View

18.

Zhao Y, Jaber V, LeBeauf A, Sharfman N, Lukiw W . microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD). Front Neurol. 2019; 10:28. PMC: 6374620. DOI: 10.3389/fneur.2019.00028. View

19.

Perot B, Menager M . Tetraspanin 7 and its closest paralog tetraspanin 6: membrane organizers with key functions in brain development, viral infection, innate immunity, diabetes and cancer. Med Microbiol Immunol. 2020; 209(4):427-436. DOI: 10.1007/s00430-020-00681-3. View

20.

Yoon S, Kim S, Ko Y, Jeong G, Lee K, Lee J . Differential expression of MicroRNAs in Alzheimer's disease: a systematic review and meta-analysis. Mol Psychiatry. 2022; 27(5):2405-2413. DOI: 10.1038/s41380-022-01476-z. View