Cutoff Points of T1 Rho/T2 Mapping Relaxation Times Distinguishing Early-stage and Advanced Osteoarthritis

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2022 Jul 14

PMID 35832709

Authors

Zhijian Yang

Chao Xie

Songwen Ou

Minning Zhao

Zhaowei Lin

Affiliations

Soon will be listed here.

Abstract

Introduction: The histopathology grading system is the gold standard post-operative method to evaluate cartilage degeneration in knee osteoarthritis (OA). Magnetic resonance imaging (MRI) T1 rho/T2 mapping imaging can be used for preoperative detection. An association between histopathology and T1 rho/T2 mapping relaxation times was suggested in previous research. However, the cutoff point was not determined among different histopathology grades. Our study aimed to determine the cutoff point of T1 rho/T2 mapping.

Material And Methods: T1 rho/T2 mapping images were acquired from 80 samples before total knee replacements. Then the histopathology grading system was applied.

Results: The mean T1 rho/T2 mapping relaxation times of 80 samples were 39.17 ms and 37.98 ms respectively. Significant differences were found in T1 rho/T2 mapping values between early-stage and advanced OA ( < 0.001). The cutoff point for T1 rho was 33 ms with a sensitivity of 94.12 (95% CI: 80-99.3) and a specificity of 91.30 (95% CI: 79.2-97.6). The cutoff point for T2 mapping was suggested as 35.04 ms with a sensitivity of 88.24 (95% CI: 72.5-96.7) and specificity of 97.83 (95% CI: 88.5-99.9). After bootstrap simulation, the 95% CI of the T1 rho/T2 mapping cutoff point was estimated as 29.36 to 36.32 ms and 34.8 to 35.04 ms respectively. The area under the PR curve of T1 rho/T2 mapping was 0.972 (95% CI: 0.925-0.992) and 0.949 (95% CI: 0.877-0.989) respectively.

Conclusions: The cutoff point of T1 rho relaxation times, which was suggested as 33 ms, could be used to distinguish early-stage and advanced OA.

Citing Articles

Synthetic Knee MRI T Maps as an Avenue for Clinical Translation of Quantitative Osteoarthritis Biomarkers.

Tong M, Tolpadi A, Bhattacharjee R, Han M, Majumdar S, Pedoia V Bioengineering (Basel). 2024; 11(1).

PMID: 38247894 PMC: 10812962. DOI: 10.3390/bioengineering11010017.

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