The Role of Acupuncture for Long COVID: Mechanisms and Models

Overview

Journal Med Acupunct

Date 2022 Jul 14

PMID 35832109

Authors

James E Williams

Jacques Moramarco

Affiliations

Soon will be listed here.

Abstract

Objective: To establish an evidence-based role for acupuncture as a safe and effective treatment for managing Long COVID in the integrative medical setting.

Background: COVID-19 progresses to a chronic state, termed Long COVID, in about 30% of cases with estimates as high as 40% for prolonged illness. Symptoms are diverse and range over several body systems, including unrelenting fatigue, persistent malaise, chronic pain, and mood changes. Early clinical reports suggest acupuncture can effectively address both symptoms and the underlying causes of Long COVID.

Evidence: Historically, acupuncture is well defined in Traditional Chinese Medicine writings to treat influenza-like febrile illnesses. Contemporary scientific literature and case studies support the value of acupuncture for symptoms associated with acute and chronic respiratory viral infections, such as influenza, including SARS and COVID-19. Recent reports provide early evidence of acupuncture's effectiveness in managing Long COVID symptoms and may also have disease-modifying benefits.

Conclusion: Acupuncture is a viable adjunctive health care modality as part of a multidisciplinary approach for symptom control and disease management to improve quality of life in Long COVID patients. Since acupuncture may favorably modify the length and outcome of this condition, the model of acupuncture presented in this article warrants broader use in the integrative clinical setting and for further research.

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References

Davis H, Assaf G, McCorkell L, Wei H, Low R, Reem Y . Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 2021; 38:101019. PMC: 8280690. DOI: 10.1016/j.eclinm.2021.101019. View

Volf N, Salques V, Lassaux A . An Auricular Marker for COVID-19. Med Acupunct. 2020; 32(4):174-175. PMC: 7464934. DOI: 10.1089/acu.2020.29151.vlf. View

Jones S, Hunter C . Is IL-6 a key cytokine target for therapy in COVID-19?. Nat Rev Immunol. 2021; 21(6):337-339. PMC: 8043092. DOI: 10.1038/s41577-021-00553-8. View

Liu Z, Li J, Chen D, Gao R, Zeng W, Chen S . Dynamic Interleukin-6 Level Changes as a Prognostic Indicator in Patients With COVID-19. Front Pharmacol. 2020; 11:1093. PMC: 7379481. DOI: 10.3389/fphar.2020.01093. View

Stefano G, Buttiker P, Weissenberger S, Martin A, Ptacek R, Kream R . Editorial: The Pathogenesis of Long-Term Neuropsychiatric COVID-19 and the Role of Microglia, Mitochondria, and Persistent Neuroinflammation: A Hypothesis. Med Sci Monit. 2021; 27:e933015. PMC: 8120907. DOI: 10.12659/MSM.933015. View

Gameil M, Marzouk R, Elsebaie A, Rozaik S . Long-term clinical and biochemical residue after COVID-19 recovery. Egypt Liver J. 2021; 11(1):74. PMC: 8435147. DOI: 10.1186/s43066-021-00144-1. View

Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P . Prolonged elevation of D-dimer levels in convalescent COVID-19 patients is independent of the acute phase response. J Thromb Haemost. 2021; 19(4):1064-1070. PMC: 8013297. DOI: 10.1111/jth.15267. View

Morris E, Neelapu S, Giavridis T, Sadelain M . Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy. Nat Rev Immunol. 2021; 22(2):85-96. PMC: 8127450. DOI: 10.1038/s41577-021-00547-6. View

Davidson A, Wysocki J, Batlle D . Interaction of SARS-CoV-2 and Other Coronavirus With ACE (Angiotensin-Converting Enzyme)-2 as Their Main Receptor: Therapeutic Implications. Hypertension. 2020; 76(5):1339-1349. PMC: 7480804. DOI: 10.1161/HYPERTENSIONAHA.120.15256. View

10.

Salamanna F, Maglio M, Landini M, Fini M . Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2. Front Med (Lausanne). 2020; 7:594495. PMC: 7744810. DOI: 10.3389/fmed.2020.594495. View

11.

Min S, Lee H, Kim S, Park J, Chae Y, Lee H . Local changes in microcirculation and the analgesic effects of acupuncture: a laser Doppler perfusion imaging study. J Altern Complement Med. 2014; 21(1):46-52. PMC: 4296745. DOI: 10.1089/acm.2013.0442. View

12.

Pan W, Fan A, Chen S, Faggert Alemi S . Acupuncture modulates immunity in sepsis: Toward a science-based protocol. Auton Neurosci. 2021; 232:102793. DOI: 10.1016/j.autneu.2021.102793. View

13.

Tsuchiya M, Sato E, Inoue M, Asada A . Acupuncture enhances generation of nitric oxide and increases local circulation. Anesth Analg. 2007; 104(2):301-7. DOI: 10.1213/01.ane.0000230622.16367.fb. View

14.

Lenze E, Mattar C, Zorumski C, Stevens A, Schweiger J, Nicol G . Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA. 2020; 324(22):2292-2300. PMC: 7662481. DOI: 10.1001/jama.2020.22760. View

15.

Boehmer A, Georgopoulos S, Nagel J, Rostock T, Bauer A, Ehrlich J . Acupuncture at the auricular branch of the vagus nerve enhances heart rate variability in humans: An exploratory study. Heart Rhythm O2. 2021; 1(3):215-221. PMC: 8183808. DOI: 10.1016/j.hroo.2020.06.001. View

16.

Shen M, Zipes D . Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res. 2014; 114(6):1004-21. DOI: 10.1161/CIRCRESAHA.113.302549. View

17.

Rubin E, Longo D, Baden L . Interleukin-6 Receptor Inhibition in Covid-19 - Cooling the Inflammatory Soup. N Engl J Med. 2021; 384(16):1564-1565. PMC: 7944949. DOI: 10.1056/NEJMe2103108. View

18.

Ho Y, Zhao F, Yeung W, Wong G, Zhang H, Chang R . Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?. Oxid Med Cell Longev. 2020; 2020:9641904. PMC: 7044481. DOI: 10.1155/2020/9641904. View

19.

Lim H, Kim M, Lee C, Namgung U . Anti-Inflammatory Effects of Acupuncture Stimulation via the Vagus Nerve. PLoS One. 2016; 11(3):e0151882. PMC: 4798687. DOI: 10.1371/journal.pone.0151882. View

20.

Paul B, Lemle M, Komaroff A, Snyder S . Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2021; 118(34). PMC: 8403932. DOI: 10.1073/pnas.2024358118. View