Concentrations of Ciprofloxacin in Human Liver, Gallbladder, and Bile After Oral Administration

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1987 Jan 1

PMID 3582488

Citations 12

Authors

M Dan

N Verbin

A Gorea

H Nagar

S A Berger

Affiliations

Soon will be listed here.

Abstract

We have measured concentrations of ciprofloxacin in serum, hepatic tissue, gallbladder, and bile in 10 patients after a single oral dose of 750 mg given before cholecystectomy. Mean liver and gallbladder tissue concentrations were 12.76 micrograms X g-1 +/- 2.79 (SEM) and 5.94 micrograms X g-1 +/- 1.35, respectively. Concentrations in bile taken from the gallbladder (7 patients) ranged from 68 to 225 micrograms X ml-1, with a mean bile/serum concentration ratio of 49. Concentrations in bile taken from the common bile duct (2 patients) were 17 and 16 micrograms X ml-1.

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References

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