Relevance of Vesico-ureteric Reflux in Development of Lipid A Antibodies in Recurrent Urinary Tract Infections in Children--a Preliminary Study

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1987 Jan 1

PMID 3582405

Citations 4

Authors

P J Mar

W Marget

K Schneider

B H Belohradsky

R Roos

Affiliations

Soon will be listed here.

Abstract

The serum titres of IgG and IgM antibodies to lipid A were measured in 24 children with chronic pyelonephritis (PN), 55 with recurrent lower urinary tract infections (LUTI), 13 with gram-negative sepsis (S), and in 50 control children using an enzyme-linked immunosorbent assay (ELISA). Children ranged in age from 1 month-17 years. Patients with PN were differentiated by the presence or absence of an acute infectious episode and/or vesico-ureteric reflux (VUR). During an acute episode in PN and LUTI, IgG titres were significantly higher than in controls, but only PN patients with an acute infectious episode also had significantly elevated IgM titres. Overall, children with LUTI showed a significantly lower frequency of detectable IgG lipid A antibodies (27%) than in PN (63%). In PN children with VUR not accompanied by an infectious episode, lipid A antibody was found at relatively low titres, while an episode not accompanied by VUR displayed significantly elevated IgG titres, and an episode accompanied by VUR showed elevation of both IgG and IgM anti-lipid A antibody titres.

Citing Articles

[Lipoid A antibody titer in humans].

Marget W Infection. 1987; 15 Suppl 2:S85-8.

PMID: 3610331 DOI: 10.1007/BF01644199.

[Lipoid A antibody titer in the human].

Marget W Infection. 1987; 15(2):142-5.

PMID: 3596812 DOI: 10.1007/BF01650220.

The last round against bacterial infections?.

Marget W Infection. 1990; 18(4):197-9.

PMID: 2210849 DOI: 10.1007/BF01643384.

Antibody responses to lipid A, core, and O sugars of the Pseudomonas aeruginosa lipopolysaccharide in chronically infected cystic fibrosis patients.

Kronborg G, Fomsgaard A, Galanos C, Freudenberg M, Hoiby N J Clin Microbiol. 1992; 30(7):1848-55.

PMID: 1378455 PMC: 265392. DOI: 10.1128/jcm.30.7.1848-1855.1992.

References

Roberts J, Suarez G, Kaack B, Kallenius G, Svenson S . Experimental pyelonephritis in the monkey. VII. Ascending pyelonephritis in the absence of vesicoureteral reflux. J Urol. 1985; 133(6):1068-75. DOI: 10.1016/s0022-5347(17)49382-7. View

Edwards D, Normand I, Prescod N, Smellie J . Disappearance of vesicoureteric reflux during long-term prophylaxis of urinary tract infection in children. Br Med J. 1977; 2(6082):285-8. PMC: 1630838. DOI: 10.1136/bmj.2.6082.285. View

Westphal O . Bacterial endotoxins. The second Carl Prausnitz Memorial Lecture. Int Arch Allergy Appl Immunol. 1975; 49(1-2):1-43. View

Kallenius G, Mollby R, Svenson S, Helin I, Hultberg H, Cedergren B . Occurrence of P-fimbriated Escherichia coli in urinary tract infections. Lancet. 1981; 2(8260-61):1369-72. DOI: 10.1016/s0140-6736(81)92797-5. View

Nissenkorn I, Gil I, SERVADIO C, Lubin E . Radionuclide cystography: the significance of retention time of the refluxed radioisotope. J Urol. 1981; 126(4):448-51. DOI: 10.1016/s0022-5347(17)54570-x. View

Galanos C, Freudenberg M, Jay F, Nerkar D, Veleva K, Brade H . Immunogenic properties of lipid A. Rev Infect Dis. 1984; 6(4):546-52. DOI: 10.1093/clinids/6.4.546. View

Marget W, Weiss M, Ruhland B . Lipid A antibody determinations using ELISA on patients at a children's hospital: a preliminary report. Infection. 1983; 11(2):84-6. DOI: 10.1007/BF01641072. View

Mattsby-Baltzer I, Claesson I, Hanson L, Jodal U, Kaijser B, Lindberg U . Antibodies to lipid A during urinary tract infection. J Infect Dis. 1981; 144(4):319-28. DOI: 10.1093/infdis/144.4.319. View

Freudenberg M, Kleine B, Galanos C . The fate of lipopolysaccharide in rats: evidence for chemical alteration in the molecule. Rev Infect Dis. 1984; 6(4):483-7. DOI: 10.1093/clinids/6.4.483. View

10.

Westenfelder M, Galanos C, Withoft A, Lang G . [Occurence, significance and clinical consequences of lipid A antibody titers in patients with urinary tract infection (author's transl)]. Infection. 1977; 5(3):144-8. DOI: 10.1007/BF01639749. View

11.

Westphal O, Jann K, Himmelspach K . Chemistry and immunochemistry of bacterial lipopolysaccharides as cell wall antigens and endotoxins. Prog Allergy. 1983; 33:9-39. View

12.

Schwartz M, COTRAN R . Common enterobacterial antigen in human chronic pyelonephritis and interstitial nephritis. An immunofluorescent study. N Engl J Med. 1973; 289(16):830-5. DOI: 10.1056/NEJM197310182891604. View

13.

Simon G, Reindke B, Marget W . [Lipid A antibody titers in pyelonephritis and other gram-negative infections (author's transl)]. Infection. 1974; 2(4):178-84. DOI: 10.1007/BF01641457. View

14.

Lebowitz R, OLBING H, PARKKULAINEN K, Smellie J . International system of radiographic grading of vesicoureteric reflux. International Reflux Study in Children. Pediatr Radiol. 1985; 15(2):105-9. DOI: 10.1007/BF02388714. View

15.

Aoki S, Imamura S, Aoki M, McCabe W . "Abacterial" and bacterial pyelonephritis. Immunofluorescent localization of bacterial antigen. N Engl J Med. 1969; 281(25):1375-82. DOI: 10.1056/NEJM196912182812501. View

16.

Schneider K, Jablonski C, Wiessner M, Kohn M, FENDEL H . Screening for vesicoureteral reflux in children using real-time sonography. Pediatr Radiol. 1984; 14(6):400-3. DOI: 10.1007/BF02343428. View

17.

Engvall E, Perlmann P . Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. J Immunol. 1972; 109(1):129-35. View