Endocannabinoid Signaling in Astrocytes

Overview

Journal Glia

Specialty Neurology

Date 2022 Jul 13

PMID 35822691

Authors

Abel Eraso-Pichot

Sandrine Pouvreau

Alexandre Olivera-Pinto

Paula Gomez-Sotres

Urszula Skupio

Giovanni Marsicano

Affiliations

Soon will be listed here.

Abstract

The study of the astrocytic contribution to brain functions has been growing in popularity in the neuroscience field. In the last years, and especially since the demonstration of the involvement of astrocytes in synaptic functions, the astrocyte field has revealed multiple functions of these cells that seemed inconceivable not long ago. In parallel, cannabinoid investigation has also identified different ways by which cannabinoids are able to interact with these cells, modify their functions, alter their communication with neurons and impact behavior. In this review, we will describe the expression of different endocannabinoid system members in astrocytes. Moreover, we will relate the latest findings regarding cannabinoid modulation of some of the most relevant astroglial functions, namely calcium (Ca ) dynamics, gliotransmission, metabolism, and inflammation.

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