The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections

Overview

Journal Front Aging

Specialty Geriatrics

Date 2022 Jul 13

PMID 35821836

Authors

Jordi B Torrelles

Blanca I Restrepo

Yidong Bai

Corinna Ross

Larry S Schlesinger

Joanne Turner

Affiliations

Soon will be listed here.

Abstract

Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.

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