L. Extract and Photodynamic Therapy Are Effective Against Spp. and Do Not Show Toxicity

Overview

Journal Int J Dent

Publisher Wiley

Specialty Dentistry

Date 2022 Jul 11

PMID 35815117

Authors

Vanessa Marques Meccatti

Larissa de Souza Moura

Juliana Guerra Pinto

Juliana Ferreira-Strixino

Amjad Abu Hasna

Livia Mara Alves Figueiredo-Godoi

Juliana Campos Junqueira

Maria Cristina Marcucci

Lucas de Paula Ramos

Claudio Antonio Talge Carvalho

Cesar Rogerio Pucci

Luciane Dias de Oliveira

Affiliations

Soon will be listed here.

Abstract

Radiotherapy induces a higher level of spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of ; the antifungal activity of , curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes "LED" on and ; and the toxicity of and curcumin in model. In order to confirm the light absorption capacity of the extract, its phototransformation potential was evaluated. The antifungal effect of , curcumin, and aPDT was evaluated over spp. Finally, the toxicity of and curcumin was evaluated on the model. The data were analyzed using the GraphPad Prism 5.0 software considering = 5%. It was found that , curcumin, and aPDT using blue LED have an antifungal effect over and . The extract of 100 mg/mL and curcumin 200 g/mL do not show toxicity on model.

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