Influence of Surface Electric Charge of Ti Implants on Osteoblastic Interaction: A Systematic Review

Overview

Journal Saudi Dent J

Specialty Dentistry

Date 2022 Jul 11

PMID 35814840

Authors

Juliana Dias Corpa Tardelli

Andrea Candido Dos Reis

Affiliations

Soon will be listed here.

Abstract

Objective: A critical analysis of the existing literature to answer "What is the influence of electrical charge of titanium alloys in the electrical interaction with osteoblastic cells for osseointegration?".

Design: This systematic review followed PRISMA. The personalized search strategy was applied in PubMed, Science Direct, Embase, and Scopus databases, furthermore, in the grey literature in the Google Scholar and ProQuest. The selection process was carried out in two stages independently by two reviewers according to the eligibility criteria. The risk of bias was also analyzed.

Results: When applying the search strategy, 306 articles were found, after removing duplicates 277 were analyzed by title and abstract, of which 33 were selected for full reading, of which 10 met the eligibility criteria. And one was included from the additional literature search. Of these, all had a low risk of bias.

Conclusions: 1. The phenomenon of osseointegration is complex and, independent of the superficial electrical charge of the implant, it may occur. To understand osseointegration, attention must be paid to the synergistic action of the electrical potential; chemical composition, intrinsic to the alloy and from surface treatment; and topography, which will determine the speed of adhesion, proliferation, and osteoblast differentiation. 2. The presence of Ca2+ deposited on the surface acts as a driving force for biomineralization that induces osteoblastic attraction and differentiation; 3. For a better understanding of the current literature, more studies are needed to describe the osteogenic regulation process through protein mediation; 4. Topography and chemical composition act as decisive parameters for cell viability independent of the attractive electrical charge.

Citing Articles

Influence of the roughness of dental implants obtained by additive manufacturing on osteoblastic adhesion and proliferation: A systematic review.

Tardelli J, Duarte Firmino A, Ferreira I, Dos Reis A Heliyon. 2023; 8(12):e12505.

PMID: 36643331 PMC: 9834751. DOI: 10.1016/j.heliyon.2022.e12505.

References

Hamouda T, Baker Jr J . Antimicrobial mechanism of action of surfactant lipid preparations in enteric Gram-negative bacilli. J Appl Microbiol. 2000; 89(3):397-403. DOI: 10.1046/j.1365-2672.2000.01127.x. View

Tardelli J, da Costa Valente M, de Oliveira T, Dos Reis A . Influence of chemical composition on cell viability on titanium surfaces: A systematic review. J Prosthet Dent. 2020; 125(3):421-425. DOI: 10.1016/j.prosdent.2020.02.001. View

Park K, Song H, Park Y . Albumin adsorption on microwave-treated titanium dioxide for dental implant materials. Colloids Surf B Biointerfaces. 2021; 208:112124. DOI: 10.1016/j.colsurfb.2021.112124. View

Zhu P, Masuda Y, Koumoto K . The effect of surface charge on hydroxyapatite nucleation. Biomaterials. 2004; 25(17):3915-21. DOI: 10.1016/j.biomaterials.2003.10.022. View

Hu X, Neoh K, Zhang J, Kang E, Wang W . Immobilization strategy for optimizing VEGF's concurrent bioactivity towards endothelial cells and osteoblasts on implant surfaces. Biomaterials. 2012; 33(32):8082-93. DOI: 10.1016/j.biomaterials.2012.07.057. View

Parisi L, Ghezzi B, Bianchi M, Toffoli A, Rossi F, Bussolati O . Titanium dental implants hydrophilicity promotes preferential serum fibronectin over albumin competitive adsorption modulating early cell response. Mater Sci Eng C Mater Biol Appl. 2020; 117:111307. DOI: 10.1016/j.msec.2020.111307. View

Wei D, Du Q, Wang S, Cheng S, Wang Y, Li B . Rapid Fabrication, Microstructure, and Investigations of a High-Performance Multilayer Coating with External, Flexible, and Silicon-Doped Hydroxyapatite Nanorods on Titanium. ACS Biomater Sci Eng. 2021; 5(9):4244-4262. DOI: 10.1021/acsbiomaterials.9b00414. View

Salari M, Aboutalebi S, Chidembo A, Nevirkovets I, Konstantinov K, Liu H . Enhancement of the electrochemical capacitance of TiO2 nanotube arrays through controlled phase transformation of anatase to rutile. Phys Chem Chem Phys. 2012; 14(14):4770-9. DOI: 10.1039/c2cp40410a. View

Loberg J, Gretzer C, Mattisson I, Ahlberg E . Electronic properties of anodized TiO2 electrodes and the effect on in vitro response. J Biomed Mater Res B Appl Biomater. 2013; 102(4):826-39. DOI: 10.1002/jbm.b.33065. View

10.

Ceylan H, Kocabey S, Gulsuner H, Balcik O, Guler M, Tekinay A . Bone-like mineral nucleating peptide nanofibers induce differentiation of human mesenchymal stem cells into mature osteoblasts. Biomacromolecules. 2014; 15(7):2407-18. DOI: 10.1021/bm500248r. View

11.

Rabea E, Badawy M, Stevens C, Smagghe G, Steurbaut W . Chitosan as antimicrobial agent: applications and mode of action. Biomacromolecules. 2003; 4(6):1457-65. DOI: 10.1021/bm034130m. View

12.

Amengual-Penafiel L, Cordova L, Constanza Jara-Sepulveda M, Branes-Aroca M, Marchesani-Carrasco F, Cartes-Velasquez R . Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry. Jpn Dent Sci Rev. 2021; 57:12-19. PMC: 7946347. DOI: 10.1016/j.jdsr.2021.01.001. View

13.

Bahl S, Shreyas P, Trishul M, Suwas S, Chatterjee K . Enhancing the mechanical and biological performance of a metallic biomaterial for orthopedic applications through changes in the surface oxide layer by nanocrystalline surface modification. Nanoscale. 2015; 7(17):7704-16. DOI: 10.1039/c5nr00574d. View

14.

Lorenzetti M, Bernardini G, Luxbacher T, Santucci A, Kobe S, Novak S . Surface properties of nanocrystalline TiO2 coatings in relation to the in vitro plasma protein adsorption. Biomed Mater. 2015; 10(4):045012. DOI: 10.1088/1748-6041/10/4/045012. View

15.

Saffarian Tousi N, Velten M, Bishop T, Leong K, Barkhordar N, Marshall G . Combinatorial effect of Si4+, Ca2+, and Mg2+ released from bioactive glasses on osteoblast osteocalcin expression and biomineralization. Mater Sci Eng C Mater Biol Appl. 2013; 33(5):2757-65. DOI: 10.1016/j.msec.2013.02.044. View

16.

Kreve S, Dos Reis A . Bacterial adhesion to biomaterials: What regulates this attachment? A review. Jpn Dent Sci Rev. 2021; 57:85-96. PMC: 8215285. DOI: 10.1016/j.jdsr.2021.05.003. View

17.

Finke B, Luethen F, Schroeder K, Mueller P, Bergemann C, Frant M . The effect of positively charged plasma polymerization on initial osteoblastic focal adhesion on titanium surfaces. Biomaterials. 2007; 28(30):4521-34. DOI: 10.1016/j.biomaterials.2007.06.028. View

18.

Anitua E, Pinas L, Alkhraisat M . Early marginal bone stability of dental implants placed in a transalveolarly augmented maxillary sinus: a controlled retrospective study of surface modification with calcium ions. Int J Implant Dent. 2017; 3(1):49. PMC: 5712506. DOI: 10.1186/s40729-017-0111-5. View

19.

Zhang W, Li Z, Huang Q, Xu L, Li J, Jin Y . Effects of a hybrid micro/nanorod topography-modified titanium implant on adhesion and osteogenic differentiation in rat bone marrow mesenchymal stem cells. Int J Nanomedicine. 2013; 8:257-65. PMC: 3548415. DOI: 10.2147/IJN.S39357. View

20.

Patil S, Sandberg A, Heckert E, Self W, Seal S . Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential. Biomaterials. 2007; 28(31):4600-7. PMC: 2259388. DOI: 10.1016/j.biomaterials.2007.07.029. View