Roles of EP Receptors in the Regulation of Fluid Balance and Blood Pressure

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2022 Jul 11

PMID 35813612

Authors

Lu Wang

Yiqian Wu

Zhanjun Jia

Jing Yu

Songming Huang

Affiliations

Soon will be listed here.

Abstract

Prostaglandin E2 (PGE2) is an important prostanoid expressing throughout the kidney and cardiovascular system. Despite the diverse effects on fluid metabolism and blood pressure, PGE2 is implicated in sustaining volume and hemodynamics homeostasis. PGE2 works through four distinct E-prostanoid (EP) receptors which are G protein-coupled receptors. To date, pharmacological specific antagonists and agonists of all four subtypes of EP receptors and genetic targeting knockout mice for each subtype have helped in uncoupling the diverse functions of PGE2 and discriminating the respective characteristics of each receptor. In this review, we summarized the functions of individual EP receptor subtypes in the renal and blood vessels and the molecular mechanism of PGE2-induced fluid metabolism and blood pressure homeostasis.

Citing Articles

Role of G protein coupled receptors in acute kidney injury.

Lv L, Liu Y, Xiong J, Wang S, Li Y, Zhang B Cell Commun Signal. 2024; 22(1):423.

PMID: 39223553 PMC: 11367933. DOI: 10.1186/s12964-024-01802-8.

Mechanisms of Abnormal Lipid Metabolism in the Pathogenesis of Disease.

Xu L, Yang Q, Zhou J Int J Mol Sci. 2024; 25(15).

PMID: 39126035 PMC: 11312913. DOI: 10.3390/ijms25158465.

From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases.

Sarb O, Sarb A, Iacobescu M, Vlad I, Milaciu M, Ciurmarnean L Int J Mol Sci. 2024; 25(11).

PMID: 38891863 PMC: 11171869. DOI: 10.3390/ijms25115676.

Vasodilation and Blood Pressure-Lowering Effect of 3-Demethyl-2-Geranyl-4-Prenylbellidifoline, a Xanthone Obtained from , in Hypertensive Rats.

Bolda Mariano L, de Cassia Vilhena da Silva R, Niero R, Filho V, Da Silva-Santos J, de Souza P Plants (Basel). 2024; 13(4).

PMID: 38498544 PMC: 10892760. DOI: 10.3390/plants13040528.

The Link between Prostanoids and Cardiovascular Diseases.

Beccacece L, Abondio P, Bini C, Pelotti S, Luiselli D Int J Mol Sci. 2023; 24(4).

PMID: 36835616 PMC: 9962914. DOI: 10.3390/ijms24044193.

References

Peebles Jr R . Prostaglandins in asthma and allergic diseases. Pharmacol Ther. 2018; 193:1-19. PMC: 6309751. DOI: 10.1016/j.pharmthera.2018.08.001. View

Hristovska A, Rasmussen L, Hansen P, Nielsen S, Nusing R, Narumiya S . Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase. Hypertension. 2007; 50(3):525-30. DOI: 10.1161/HYPERTENSIONAHA.107.088948. View

Hubich A, Sholukh M . Biochemistry of prostaglandins A. Biochemistry (Mosc). 2006; 71(3):229-38. DOI: 10.1134/s0006297906030011. View

Gonzalez A, Cespedes C, Villanueva S, Michea L, Vio C . E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II. Biochem Biophys Res Commun. 2009; 389(2):372-7. DOI: 10.1016/j.bbrc.2009.08.157. View

Wang L, Xiao Y, Fang J, Wang J, Zhang H, Meng X . PGF stimulates the 10-pS Cl channel and thiazide-sensitive Na-Cl cotransporter in the distal convoluted tubule. Am J Physiol Renal Physiol. 2020; 319(3):F414-F422. DOI: 10.1152/ajprenal.00287.2020. View

Hao C, Breyer M . Physiological regulation of prostaglandins in the kidney. Annu Rev Physiol. 2007; 70:357-77. DOI: 10.1146/annurev.physiol.70.113006.100614. View

Prieto I, Villarejo A, Segarra A, Banegas I, Wangensteen R, Martinez-Canamero M . Brain, heart and kidney correlate for the control of blood pressure and water balance: role of angiotensinases. Neuroendocrinology. 2014; 100(2-3):198-208. DOI: 10.1159/000368835. View

Hatae N, Sugimoto Y, Ichikawa A . Prostaglandin receptors: advances in the study of EP3 receptor signaling. J Biochem. 2002; 131(6):781-4. DOI: 10.1093/oxfordjournals.jbchem.a003165. View

Imig J, Breyer M, Breyer R . Contribution of prostaglandin EP(2) receptors to renal microvascular reactivity in mice. Am J Physiol Renal Physiol. 2002; 283(3):F415-22. DOI: 10.1152/ajprenal.00351.2001. View

10.

Hebert R, Jacobson H, Breyer M . Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium. J Clin Invest. 1991; 87(6):1992-8. PMC: 296953. DOI: 10.1172/JCI115227. View

11.

Rouch A, Kudo L . Role of PGE(2) in alpha(2)-induced inhibition of AVP- and cAMP-stimulated H(2)O, Na(+), and urea transport in rat IMCD. Am J Physiol Renal Physiol. 2000; 279(2):F294-301. DOI: 10.1152/ajprenal.2000.279.2.F294. View

12.

Bjarnason I, Scarpignato C, Holmgren E, Olszewski M, Rainsford K, Lanas A . Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology. 2017; 154(3):500-514. DOI: 10.1053/j.gastro.2017.10.049. View

13.

Li J, Chou C, Li B, Gavrilova O, Eisner C, Schnermann J . A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. J Clin Invest. 2009; 119(10):3115-26. PMC: 2752083. DOI: 10.1172/JCI39680. View

14.

Zelenina M, Christensen B, Palmer J, Nairn A, Nielsen S, Aperia A . Prostaglandin E(2) interaction with AVP: effects on AQP2 phosphorylation and distribution. Am J Physiol Renal Physiol. 2000; 278(3):F388-94. DOI: 10.1152/ajprenal.2000.278.3.F388. View

15.

Tilley S, Audoly L, Hicks E, Kim H, Flannery P, Coffman T . Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. J Clin Invest. 1999; 103(11):1539-45. PMC: 408376. DOI: 10.1172/JCI6579. View

16.

Olesen E, Rutzler M, Moeller H, Praetorius H, Fenton R . Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A. 2011; 108(31):12949-54. PMC: 3150913. DOI: 10.1073/pnas.1104691108. View

17.

Nasrallah R, Zimpelmann J, Eckert D, Ghossein J, Geddes S, Beique J . PGE EP receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct. Lab Invest. 2017; 98(3):360-370. DOI: 10.1038/labinvest.2017.133. View

18.

Schweda F, Klar J, Narumiya S, Nusing R, Kurtz A . Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys. Am J Physiol Renal Physiol. 2004; 287(3):F427-33. DOI: 10.1152/ajprenal.00072.2004. View

19.

Chen L, Miao Y, Zhang Y, Dou D, Liu L, Tian X . Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor response via decreasing arterial contractility. Arterioscler Thromb Vasc Biol. 2012; 32(12):3024-32. PMC: 3565847. DOI: 10.1161/ATVBAHA.112.254052. View

20.

Chi Y, Jasmin J, Seki Y, Lisanti M, Charron M, Lefer D . Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice. PLoS One. 2015; 10(6):e0131735. PMC: 4488299. DOI: 10.1371/journal.pone.0131735. View