Mixture Math: Deciding What to Add in a Cumulative Risk Assessment

Overview

Journal Curr Opin Toxicol

Date 2022 Jul 11

PMID 35813121

Authors

Cynthia V Rider

Affiliations

Soon will be listed here.

Abstract

Component-based approaches for cumulative risk assessment provide an important tool for informing public health policy. While current quantitative cumulative risk assessments focus narrowly on pesticides that share a mechanism of action, growing scientific evidence supports expansion of their application to encompass stressors that target a common disease. Case studies have demonstrated dose additive effects of chemicals with different mechanisms of action on liver steatosis, craniofacial malformations, and male reproductive tract developmental disruption. Evidence also suggests that nonchemical stressors such as noise or psychosocial stress can modify effects of chemicals. Focused research attention is required before nonchemical stressors can routinely be included in quantitative cumulative risk assessments.

Citing Articles

Combined Exposures and Mixtures Research: An Enduring NIEHS Priority.

Carlin D, Rider C Environ Health Perspect. 2024; 132(7):75001.

PMID: 38968090 PMC: 11225971. DOI: 10.1289/EHP14340.

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