A Comparative Field Evaluation of the Effect of Growth Performance Between Porcine Circovirus Type 2a (PCV2a)- and PCV2b-Based Bivalent Vaccines Containing PCV2 and

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2022 Jul 11

PMID 35812885

Authors

Hyejean Cho

Taehwan Oh

Jeongmin Suh

Chanhee Chae

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to compare two different bivalent vaccines containing porcine circovirus type 2 (PCV2) and . One vaccine contained PCV2a and the other contained PCV2b, and both were administered on a farm suffering from subclinical PCV2d infection and enzootic pneumonia. A total of 180 pigs were randomly divided into 3 groups (60 pigs per group; male pigs = 30 and female pigs = 30). Bivalent vaccination significantly improved growth performance in both vaccinated groups as compared to the unvaccinated (UnVac) group. Growth performance measured by body weight and average daily weight gain (ADWG) was not significantly different between the two bivalent-vaccinated groups (VacA and VacB). Both bivalent vaccines elicited high levels of neutralizing antibodies and interferon-γ secreting cells (IFN-γ-SC) against PCV2d, leading to a reduction in the levels of PCV2d blood viral load as compared to unvaccinated animals. Similarly, both bivalent vaccines elicited high levels of IFN-γ-SC against that reduced the level of laryngeal viral loads as compared to unvaccinated animals. Significant differences in severity of lung and lymphoid lesions were observed in both vaccinated groups as compared to the UnVac group. These comparative field data demonstrated that both bivalent vaccines are good candidates for controlling subclinical PCV2d infection and enzootic pneumonia in swine farms suffering from an existing infection.

Citing Articles

Detection of PCV2d in Vaccinated Pigs in Colombia and Prediction of Vaccine T Cell Epitope Coverage against Circulating Strains Using EpiCC Analysis.

Vargas-Bermudez D, Gil-Silva A, Naranjo-Ortiz M, Mogollon J, Gomez-Betancur J, Estrada J Vaccines (Basel). 2024; 12(10).

PMID: 39460286 PMC: 11511301. DOI: 10.3390/vaccines12101119.

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