Metabolomic Profiling of Samples from Pediatric Patients with Asthma Unveils Deficient Nutrients in African Americans

Overview

Journal iScience

Publisher Cell Press

Date 2022 Jul 11

PMID 35811841

Authors

Hui-Qi Qu

Joseph Glessner

Jingchun Qu

Steven Gilhool

Frank Mentch

Ian Campbell

Patrick Sleiman

John J Connolly

Hakon Hakonarson

Affiliations

Soon will be listed here.

Abstract

Plasma metabolomics represents a potentially powerful approach to understand the biochemical mechanisms of nutrition and metabolism in asthma. This study aims to acquire knowledge on plasma metabolites in asthma, which may provide avenues for nutrition therapy, as well as explanations for the observed effects in existing therapies. This study investigated 249 metabolites from 18 metabolite groups in a large cohort of African American population, including 602 pediatric patients with asthma and 593 controls, using a nuclear magnetic resonance (NMR) metabolomics platform. Decreased levels of citrate, ketone bodies, and two amino acids histidine (His) and glutamine (Gln), were observed in asthma cases compared to controls. Metabolites for lipid metabolism lost significance after controlling for comorbid obesity. For the first time, this study depicts a broad panorama of lipid metabolism and nutrition in asthma. Supplementation or augmentation of nutrients that are deficient may be beneficial for asthma care.

Citing Articles

Association of Whole Blood Amino Acid and Acylcarnitine Metabolome with Anthropometry and IGF-I Serum Levels in Healthy Children and Adolescents in Germany.

Jensch R, Baber R, Korner A, Kiess W, Ceglarek U, Garten A Metabolites. 2024; 14(9).

PMID: 39330496 PMC: 11433988. DOI: 10.3390/metabo14090489.

Sex differences in plasma metabolites in a guinea pig model of allergic asthma.

Barosova R, Baranovicova E, Adamcakova J, Prso K, Hanusrichterova J, Mokra D Physiol Res. 2024; 72(S5):S499-S508.

PMID: 38165754 PMC: 10861256. DOI: 10.33549/physiolres.935218.

Metabolomics Applied to Pediatric Asthma: What Have We Learnt in the Past 10 Years?.

Ferraro V, Zanconato S, Carraro S Children (Basel). 2023; 10(9).

PMID: 37761413 PMC: 10529856. DOI: 10.3390/children10091452.

Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review.

Makrinioti H, Zhu Z, Camargo Jr C, Fainardi V, Hasegawa K, Bush A Metabolites. 2023; 13(3).

PMID: 36984768 PMC: 10054720. DOI: 10.3390/metabo13030328.

References

Yamauchi K . [Regulation of gene expression of L-histidine decarboxylase and histamine N-methyl-transferase, and its relevance to the pathogenesis of bronchial asthma]. Nihon Rinsho. 1996; 54(2):377-88. View

Berthon B, Wood L . Nutrition and respiratory health--feature review. Nutrients. 2015; 7(3):1618-43. PMC: 4377870. DOI: 10.3390/nu7031618. View

Rojas-Morales P, Pedraza-Chaverri J, Tapia E . Ketone bodies, stress response, and redox homeostasis. Redox Biol. 2020; 29:101395. PMC: 6911969. DOI: 10.1016/j.redox.2019.101395. View

Moffett J, Puthillathu N, Vengilote R, Jaworski D, Namboodiri A . Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis-Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases. Front Physiol. 2020; 11:580167. PMC: 7689297. DOI: 10.3389/fphys.2020.580167. View

Arshi M, Cardinal J, Hill R, Davies P, Wainwright C . Asthma and insulin resistance in children. Respirology. 2010; 15(5):779-84. DOI: 10.1111/j.1440-1843.2010.01767.x. View

Wendell S, Baffi C, Holguin F . Fatty acids, inflammation, and asthma. J Allergy Clin Immunol. 2014; 133(5):1255-64. PMC: 4417548. DOI: 10.1016/j.jaci.2013.12.1087. View

Vinding R, Stokholm J, Chawes B, Bisgaard H . Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization. J Allergy Clin Immunol. 2015; 137(1):68-74.e4. DOI: 10.1016/j.jaci.2015.05.033. View

Petrus P, Lecoutre S, Dollet L, Wiel C, Sulen A, Gao H . Glutamine Links Obesity to Inflammation in Human White Adipose Tissue. Cell Metab. 2019; 31(2):375-390.e11. DOI: 10.1016/j.cmet.2019.11.019. View

Beuther D, Weiss S, Sutherland E . Obesity and asthma. Am J Respir Crit Care Med. 2006; 174(2):112-9. PMC: 2662903. DOI: 10.1164/rccm.200602-231PP. View

10.

Delmastro-Greenwood M, Freeman B, Wendell S . Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids. Annu Rev Physiol. 2013; 76:79-105. PMC: 4030715. DOI: 10.1146/annurev-physiol-021113-170341. View

11.

Bikle D . Vitamin D and bone. Curr Osteoporos Rep. 2012; 10(2):151-9. PMC: 3688475. DOI: 10.1007/s11914-012-0098-z. View

12.

Niu Y, Feng R, Hou Y, Li K, Kang Z, Wang J . Histidine and arginine are associated with inflammation and oxidative stress in obese women. Br J Nutr. 2011; 108(1):57-61. DOI: 10.1017/S0007114511005289. View

13.

Fintini D, Cianfarani S, Cofini M, Andreoletti A, Ubertini G, Cappa M . The Bones of Children With Obesity. Front Endocrinol (Lausanne). 2020; 11:200. PMC: 7193990. DOI: 10.3389/fendo.2020.00200. View

14.

Papamichael M, Katsardis C, Sarandi E, Georgaki S, Frima E, Varvarigou A . Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment. Metabolites. 2021; 11(4). PMC: 8072856. DOI: 10.3390/metabo11040251. View

15.

Cao J . Effects of obesity on bone metabolism. J Orthop Surg Res. 2011; 6:30. PMC: 3141563. DOI: 10.1186/1749-799X-6-30. View

16.

Reinke S, Gallart-Ayala H, Gomez C, Checa A, Fauland A, Naz S . Metabolomics analysis identifies different metabotypes of asthma severity. Eur Respir J. 2017; 49(3). PMC: 5399350. DOI: 10.1183/13993003.01740-2016. View

17.

Ebell M, Hall S, Rustin R, Powell-Threets K, Munoz L, Toodle K . A Multicomponent, Multi-Trigger Intervention to Enhance Asthma Control in High-Risk African American Children. Prev Chronic Dis. 2019; 16:E69. PMC: 6549433. DOI: 10.5888/pcd16.180387. View

18.

Viljakainen H, Ivaska K, Paldanius P, Lipsanen-Nyman M, Saukkonen T, Pietilainen K . Suppressed bone turnover in obesity: a link to energy metabolism? A case-control study. J Clin Endocrinol Metab. 2014; 99(6):2155-63. DOI: 10.1210/jc.2013-3097. View

19.

Gerber D, Tanenbaum L, Ahrens M . Free serum histidine levels in patients with rheumatoid arthritis and control subjects following an oral load of free L-histidine. Metabolism. 1976; 25(6):655-7. DOI: 10.1016/0026-0495(76)90062-7. View

20.

Smith P, Howitt M, Panikov N, Michaud M, Gallini C, Bohlooly-Y M . The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013; 341(6145):569-73. PMC: 3807819. DOI: 10.1126/science.1241165. View