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Exercise-induced Hypoalgesia (EIH) in Response to Different Exercise Intensities

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Specialty Physiology
Date 2022 Jul 9
PMID 35809091
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Abstract

Purpose: Acute physical activity leads to exercise-induced hypoalgesia (EIH). The aim of this study was to investigate the effects of four different exercise intensities on EIH.

Methods: 25 male (age: 24.7 ± 3.0) subjects underwent four different exercise sessions on a bicycle ergometer for 30 min each at 60, 80, 100, and 110% of the individual anaerobic threshold on separate days in a randomized crossover design. Before, as well as 5- and 45-min post-exercise, pain sensitivity was measured employing pain pressure thresholds (PPT) at the elbow, knee, and ankle joints as well as the sternum and forehead. Besides, conditioned pain modulation (CPM) was conducted using thermal test- and conditioned stimuli before, 5-, and 45-min post-exercise.

Results: A main time effect was observed regarding PPT at all landmarks except for the forehead with higher values observed 5 and 45 min post-exercise compared to the pre-values. Yet, no interaction effects occurred. CPM did not change in response to any of the intensities used.

Conclusion: EIH occurs 5 and 45 min after exercise regardless of the intensity used at the joints and sternum which might be explained by local pain-inhibiting pathways and probably to a limited degree by central mechanisms, as no hypoalgesia was observed at the forehead and no changes in CPM occurred.

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References
1.
Micalos P, Arendt-Nielsen L . Differential pain response at local and remote muscle sites following aerobic cycling exercise at mild and moderate intensity. Springerplus. 2016; 5:91. PMC: 4729757. DOI: 10.1186/s40064-016-1721-8. View

2.
Petrini L, Matthiesen S, Arendt-Nielsen L . The effect of age and gender on pressure pain thresholds and suprathreshold stimuli. Perception. 2015; 44(5):587-96. DOI: 10.1068/p7847. View

3.
Dietrich A, McDaniel W . Endocannabinoids and exercise. Br J Sports Med. 2004; 38(5):536-41. PMC: 1724924. DOI: 10.1136/bjsm.2004.011718. View

4.
Yarnitsky D, Bouhassira D, Drewes A, Fillingim R, Granot M, Hansson P . Recommendations on practice of conditioned pain modulation (CPM) testing. Eur J Pain. 2014; 19(6):805-6. DOI: 10.1002/ejp.605. View

5.
Malfliet A, Pas R, Brouns R, De Win J, Hatem S, Meeus M . Cerebral Blood Flow and Heart Rate Variability in Chronic Fatigue Syndrome: A Randomized Cross-Over Study. Pain Physician. 2018; 21(1):E13-E24. View