Vitamin D Levels in a Population from Argentina with Metabolic Disorders

Overview

Journal Porto Biomed J

Publisher Wolters Kluwer

Specialty Biomedical Engineering

Date 2022 Jul 8

PMID 35801218

Authors

Maria Constanza Luciardi

Mariano Nicolas Aleman

Daniela Martinez

Mirta Centeno Maxzud

Analia Soria

Mirta Ester Aldonati

Hector Lucas Luciardi

Affiliations

Soon will be listed here.

Abstract

Methods: This observational study with a cross-sectional design included 151 patients with metabolic disorders (type 2 diabetes, hypothyroidism, type 2 diabetes with hypothyroidism, and excess weight). A fasting blood sample was collected and analyzed to determine the levels of 25-hydroxyvitamin D, calcium, glucose, hemoglobin A1c, thyroid-stimulating hormone, and free thyroxine. Anthropometric and blood pressure measurements were also performed.

Results: According to vitamin D values established by the Institute of Medicine, subjects with metabolic disorders group showed: 23% risk to bone health (9.42 ±3.O4ng/mL), 45% risk of insufficiency/deficiency (17.05 ±2.12ng/mL), and 32% had sufficient levels (26.34±6.74ng/mL), whereas healthy subjects group showed significantly higher values than metabolic diseases group (37.25± 7.72). In addition, vitamin D levels were inversely correlated with elevated body mass index (29.13±5.15kg/m), systolic blood pressure (126.50± 15.60 mm Hg), fast blood glucose (106.29±33.80 mg/dL), and hemoglobin A1c (6.40% ± 1.38%) values.

Conclusion: Subjects with metabolic disorders and with adequate nutritional intake of vitamin D-rich foods and frequent exposure to sunlight have low serum vitamin D concentrations compared to the general population and vitamin D status should be assessed in these patients.

Citing Articles

Chronic kidney disease prevalence in asymptomatic patients with risk factors-usefulness of serum cystatin C: a cross-sectional study.

Avila M, Luciardi M, Oldano A, Aleman M, Perez Aguilar R Porto Biomed J. 2023; 8(6):e233.

PMID: 38093795 PMC: 10715761. DOI: 10.1097/j.pbj.0000000000000233.

Vitamin D and the Thyroid: A Critical Review of the Current Evidence.

Babic Leko M, Juresko I, Rozic I, Pleic N, Gunjaca I, Zemunik T Int J Mol Sci. 2023; 24(4).

PMID: 36835005 PMC: 9964959. DOI: 10.3390/ijms24043586.

References

Park J, Pichiah P, Cha Y . Vitamin D and Metabolic Diseases: Growing Roles of Vitamin D. J Obes Metab Syndr. 2019; 27(4):223-232. PMC: 6513299. DOI: 10.7570/jomes.2018.27.4.223. View

Senyigit A . The association between 25-hydroxy vitamin D deficiency and diabetic complications in patients with type 2 diabetes mellitus. Diabetes Metab Syndr. 2019; 13(2):1381-1386. DOI: 10.1016/j.dsx.2019.01.043. View

Palacios C, Gonzalez L . Is vitamin D deficiency a major global public health problem?. J Steroid Biochem Mol Biol. 2013; 144 Pt A:138-45. PMC: 4018438. DOI: 10.1016/j.jsbmb.2013.11.003. View

Gaksch M, Jorde R, Grimnes G, Joakimsen R, Schirmer H, Wilsgaard T . Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS One. 2017; 12(2):e0170791. PMC: 5312926. DOI: 10.1371/journal.pone.0170791. View

Jeong H, Park K, Lee M, Yang D, Kim S, Lee S . Vitamin D and Hypertension. Electrolyte Blood Press. 2017; 15(1):1-11. PMC: 5641496. DOI: 10.5049/EBP.2017.15.1.1. View

Puche R . [On the prevalence of hypovitaminosis D in Argentina]. Medicina (B Aires). 2015; 75(3):183-6. View

AlMetwazi M, Noor A, Almasri D, Popovici I, Alhawassi T, Alburikan K . The association of vitamin D deficiency and glucose control among diabetic patients. Saudi Pharm J. 2018; 25(8):1179-1183. PMC: 6111131. DOI: 10.1016/j.jsps.2017.09.001. View

Engin A . The Definition and Prevalence of Obesity and Metabolic Syndrome. Adv Exp Med Biol. 2017; 960:1-17. DOI: 10.1007/978-3-319-48382-5_1. View

Alloubani A, Akhu-Zaheya L, Samara R, Abdulhafiz I, Saleh A, Altowijri A . Relationship between Vitamin D Deficiency, Diabetes, and Obesity. Diabetes Metab Syndr. 2019; 13(2):1457-1461. DOI: 10.1016/j.dsx.2019.02.021. View

10.

Leung P . The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus. Nutrients. 2016; 8(3):147. PMC: 4808876. DOI: 10.3390/nu8030147. View

11.

Urrunaga-Pastor D, Guarnizo-Poma M, Macollunco-Flores P, Lazaro-Alcantara H, Paico-Palacios S, Pantoja-Torres B . Association between vitamin D deficiency and insulin resistance markers in euthyroid non-diabetic individuals. Diabetes Metab Syndr. 2019; 13(1):258-263. DOI: 10.1016/j.dsx.2018.09.008. View

12.

Moreira J, de Paula T, Sperb L, Miller M, Azevedo M, Viana L . Association of plasma vitamin D status with lifestyle patterns and ambulatory blood pressure monitoring parameters in patients with type 2 diabetes and hypertension. Diabetes Res Clin Pract. 2018; 139:139-146. DOI: 10.1016/j.diabres.2018.02.038. View

13.

Ozfirat Z, Chowdhury T . Vitamin D deficiency and type 2 diabetes. Postgrad Med J. 2010; 86(1011):18-25. DOI: 10.1136/pgmj.2009.078626. View

14.

Nayak S, Ramnanansingh T . Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure. BMJ Open Diabetes Res Care. 2016; 4(1):e000285. PMC: 5073486. DOI: 10.1136/bmjdrc-2016-000285. View

15.

Delle Monache S, Di Fulvio P, Iannetti E, Valerii L, Capone L, Nespoli M . Body mass index represents a good predictor of vitamin D status in women independently from age. Clin Nutr. 2018; 38(2):829-834. DOI: 10.1016/j.clnu.2018.02.024. View

16.

Chaker L, Bianco A, Jonklaas J, Peeters R . Hypothyroidism. Lancet. 2017; 390(10101):1550-1562. PMC: 6619426. DOI: 10.1016/S0140-6736(17)30703-1. View

17.

Bener A, Ozdenkaya Y, Al-Hamaq A, Barisik C, Ozturk M . Low Vitamin D Deficiency Associated With Thyroid Disease Among Type 2 Diabetic Mellitus Patients. J Clin Med Res. 2018; 10(9):707-714. PMC: 6089577. DOI: 10.14740/jocmr3507w. View

18.

Wamberg L, Pedersen S, Rejnmark L, Richelsen B . Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review. Curr Obes Rep. 2015; 4(4):429-40. DOI: 10.1007/s13679-015-0176-5. View

19.

Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;.... Circulation. 2009; 120(16):1640-5. DOI: 10.1161/CIRCULATIONAHA.109.192644. View

20.

Manson J, Brannon P, Rosen C, Taylor C . Vitamin D Deficiency - Is There Really a Pandemic?. N Engl J Med. 2016; 375(19):1817-1820. DOI: 10.1056/NEJMp1608005. View