Brain Network Modulation in Alzheimer's Disease: Clinical Phenotypes and Windows of Opportunity

Overview

Journal Neural Regen Res

Date 2022 Jul 8

PMID 35799521

Authors

Lorenzo Pini

Affiliations

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References

Quiroz Y, Schultz A, Chen K, Protas H, Brickhouse M, Fleisher A . Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol. 2015; 72(8):912-9. PMC: 4625544. DOI: 10.1001/jamaneurol.2015.1099. View

Tetreault A, Phan T, Orlando D, Lyu I, Kang H, Landman B . Network localization of clinical, cognitive, and neuropsychiatric symptoms in Alzheimer's disease. Brain. 2020; 143(4):1249-1260. PMC: 7174048. DOI: 10.1093/brain/awaa058. View

Pezzulo G, Zorzi M, Corbetta M . The secret life of predictive brains: what's spontaneous activity for?. Trends Cogn Sci. 2021; 25(9):730-743. PMC: 8363551. DOI: 10.1016/j.tics.2021.05.007. View

Pini L, Manenti R, Cotelli M, Pizzini F, Frisoni G, Pievani M . Non-Invasive Brain Stimulation in Dementia: A Complex Network Story. Neurodegener Dis. 2019; 18(5-6):281-301. DOI: 10.1159/000495945. View

Pievani M, Filippini N, van den Heuvel M, Cappa S, Frisoni G . Brain connectivity in neurodegenerative diseases--from phenotype to proteinopathy. Nat Rev Neurol. 2014; 10(11):620-33. DOI: 10.1038/nrneurol.2014.178. View

Doelling K, Assaneo M . Neural oscillations are a start toward understanding brain activity rather than the end. PLoS Biol. 2021; 19(5):e3001234. PMC: 8121326. DOI: 10.1371/journal.pbio.3001234. View

Schultz A, Chhatwal J, Hedden T, Mormino E, Hanseeuw B, Sepulcre J . Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. J Neurosci. 2017; 37(16):4323-4331. PMC: 5413178. DOI: 10.1523/JNEUROSCI.3263-16.2017. View

Warren J, Rohrer J, Schott J, Fox N, Hardy J, Rossor M . Molecular nexopathies: a new paradigm of neurodegenerative disease. Trends Neurosci. 2013; 36(10):561-9. PMC: 3794159. DOI: 10.1016/j.tins.2013.06.007. View

Pini L, Pizzini F, Boscolo-Galazzo I, Ferrari C, Galluzzi S, Cotelli M . Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation. Neurobiol Aging. 2021; 111:24-34. DOI: 10.1016/j.neurobiolaging.2021.11.005. View

10.

Pini L, Geroldi C, Galluzzi S, Baruzzi R, Bertocchi M, Chito E . Age at onset reveals different functional connectivity abnormalities in prodromal Alzheimer's disease. Brain Imaging Behav. 2020; 14(6):2594-2605. DOI: 10.1007/s11682-019-00212-6. View

11.

van den Heuvel M, Sporns O . A cross-disorder connectome landscape of brain dysconnectivity. Nat Rev Neurosci. 2019; 20(7):435-446. PMC: 8864539. DOI: 10.1038/s41583-019-0177-6. View

12.

Graff-Radford J, Yong K, Apostolova L, Bouwman F, Carrillo M, Dickerson B . New insights into atypical Alzheimer's disease in the era of biomarkers. Lancet Neurol. 2021; 20(3):222-234. PMC: 8056394. DOI: 10.1016/S1474-4422(20)30440-3. View

13.

Musiek E, Bennett D . Aducanumab and the "post-amyloid" era of Alzheimer research?. Neuron. 2021; 109(19):3045-3047. PMC: 9308468. DOI: 10.1016/j.neuron.2021.09.007. View

14.

Fox M . Mapping Symptoms to Brain Networks with the Human Connectome. N Engl J Med. 2018; 379(23):2237-2245. DOI: 10.1056/NEJMra1706158. View

15.

Pini L, Wennberg A, Salvalaggio A, Vallesi A, Pievani M, Corbetta M . Breakdown of specific functional brain networks in clinical variants of Alzheimer's disease. Ageing Res Rev. 2021; 72:101482. DOI: 10.1016/j.arr.2021.101482. View