Ultrasmall AgBiSe Nanodots for CT/thermal Imaging-guided Photothermal Tumor Therapy in the NIR-II Biowindow

Stimulus-responsive ternary chalcogenide nanomaterials are regarded as promising 'all-in-one' nanotheranostics agents on account of their tunable band structures and multi-metal intrinsic properties. Herein, ultrasmall AgBiSe nanodots are prepared by a simple thermal injection method. It shows a narrow band gap of 0.91 eV and high absorption coefficient in the NIR-II biowindow, resulting in excellent photothermal performance. Under the irradiation of a 1064 nm laser, AgBiSe can induce the overexpression of intracellular heat shock protein (Hsp70) and cell apoptosis to inhibit the growth of tumor cells. The strong signal from CT/thermal imaging also provides guidance for tumor diagnosis. Importantly, AgBiSe can be rapidly excreted from the body, thus avoiding long term toxicity. This study presents the first biomedical application of AgBiSe nanodots in cancer treatment and extends the development of ternary chalcogenide-based semiconductor nanomedicine.