A Poultry Subclinical Necrotic Enteritis Disease Model Based on Natural Uptake
Overview
Affiliations
Necrotic enteritis (NE) in poultry is an opportunistic infection caused by . Well-known as a multifactorial disease, NE development is under the influence of a wide range of environmental risk factors that promote the proliferation of pathogenic at the expense of nonpathogenic strains. Current NE challenge models typically incorporate pre-exposure to disease risk factors, in combination with exogenous inoculation. Our goal was to enhance current models using a natural uptake of from the barn environment to produce a subclinical infection. We incorporated access to litter, coccidial exposure (either 10× or 15× of the manufacturer-recommended Coccivac B52 vaccine challenge; provided unspecified doses of , and two strains of ), feed composition, and feed withdrawal stress, and achieved the commonly observed NE infection peak at 3 weeks post-hatch. NE severity was evaluated based on gut lesion pathology, clinical signs, and mortality rate. Under cage-reared conditions, 15× coccidial vaccine-challenged birds showed overall NE lesion prevalence that was 8-fold higher than 10× coccidial vaccine-challenged birds. NE-associated mortality was observed only in a floor-reared flock after a 15× coccidial vaccine challenge.
The Unique Capability of Endolysin to Tackle Antibiotic Resistance: Cracking the Barrier.
Sabur A, Khan A, Borphukan B, Razzak A, Salimullah M, Khatun M J Xenobiot. 2025; 15(1).
PMID: 39997362 PMC: 11856723. DOI: 10.3390/jox15010019.
Shamshirgaran M, Golchin M Front Vet Sci. 2024; 11:1429637.
PMID: 39113718 PMC: 11304537. DOI: 10.3389/fvets.2024.1429637.
Yang T, Sun Y, Dai Z, Liu J, Xiao S, Liu Y Animals (Basel). 2023; 13(24).
PMID: 38136821 PMC: 10741131. DOI: 10.3390/ani13243784.
Liu L, Sui W, Yang Y, Liu L, Li Q, Guo A Animals (Basel). 2022; 12(24).
PMID: 36552471 PMC: 9774581. DOI: 10.3390/ani12243552.