Metabolomics of Blood Reveals Age-dependent Pathways in Parkinson's Disease

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2022 Jul 6

PMID 35794650

Authors

Nicola DAscenzo

Emanuele Antonecchia

Antonella Angiolillo

Victor Bender

Marco Camerlenghi

Qingguo Xie

Alfonso di Costanzo

Affiliations

Soon will be listed here.

Abstract

Background: Parkinson's Disease (PD) is the second most frequent degenerative disorder, the risk of which increases with age. A preclinical PD diagnostic test does not exist. We identify PD blood metabolites and metabolic pathways significantly correlated with age to develop personalized age-dependent PD blood biomarkers.

Results: We found 33 metabolites producing a receiver operating characteristic (ROC) area under the curve (AUC) value of 97%. PCA revealed that they belong to three pathways with distinct age-dependent behavior: glycine, threonine and serine metabolism correlates with age only in PD patients; unsaturated fatty acids biosynthesis correlates with age only in a healthy control group; and, finally, tryptophan metabolism characterizes PD but does not correlate with age.

Conclusions: The targeted analysis of the blood metabolome proposed in this paper allowed to find specific age-related metabolites and metabolic pathways. The model offers a promising set of blood biomarkers for a personalized age-dependent approach to the early PD diagnosis.

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