Fucosylation Promotes Cytolytic Function and Accumulation of NK Cells in B Cell Lymphoma

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jul 5

PMID 35784355

Authors

Xing Tong

Yuhua Ru

Jianhong Fu

Ying Wang

Jinjin Zhu

Yiyang Ding

Fulian Lv

Menglu Yang

Xiya Wei

Chenchen Liu

Xin Liu

Lei Lei

Xiaojin Wu

Lingchuan Guo

Yang Xu

Jie Li

Peng Wu

Huanle Gong

Jia Chen

Depei Wu

Affiliations

Soon will be listed here.

Abstract

Natural killer (NK) cells have been demonstrated as a promising cellular therapy as they exert potent anti-tumor immune responses. However, applications of NK cells to tumor immunotherapy, especially in the treatment of advanced hematopoietic and solid malignancies, are still limited due to the compromised survival and short persistence of the transferred NK cells . Here, we observed that fucosyltransferase (FUT) 7 and 8 were highly expressed on NK cells, and the expression of CLA was positively correlated with the accumulation of NK cells in clinical B cell lymphoma development. enzyme-mediated cell-surface fucosylation, the cytolytic effect of NK cells against B cell lymphoma was significantly augmented. Fucosylation also promoted NK cell accumulation in B cell lymphoma-targeted tissues by enhancing their binding to E-selectin. Moreover, fucosylation of NK cells also facilitated stronger T cell anti-tumor immune responses. These findings suggest that fucosylation contributes to enhancing the effector functions of NK cells and may serve as a novel strategy for tumor immunotherapy.

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