T-Follicular-Like CD8 T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jul 5

PMID 35784304

Authors

Luis Romero-Martin

Ferran Tarres-Freixas

Nuria Pedreno-Lopez

Maria L Rodriguez de la Concepcion

Francesc Cunyat

Dennis Hartigan-OConnor

Jorge Carrillo

Beatriz Mothe

Julia Blanco

Marta Ruiz-Riol

Christian Brander

Alex Olvera

Affiliations

Soon will be listed here.

Abstract

T cell responses are considered critical for the control of HIV, but the contribution of different T cell subsets to this control remains unclear. Using a boosted flow cytometric approach that is able to differentiate CD4 and CD8 T cell Th1/Tc1, Th2/Tc2, Th17/Tc17, Treg and Tfh/Tfc-like HIV-specific T cell populations, we identified CD8 Tfc responses that were related to HIV plasma viral loads and associated with rate of antibody isotype class switching to IgG. This favorable balance towards IgG responses positively correlated with increased virus neutralization, higher avidity of neutralizing antibodies and more potent antibody-dependent cell cytotoxicity (ADCC) in PBMCs from HIV controllers compared to non-controllers. Our results identified the CD8 Tfc-like T-cell response as a component of effective virus control which could possibly be exploited therapeutically.

Citing Articles

HIV T-cell immunogen design and delivery.

Brander C, Hartigan-OConnor D Curr Opin HIV AIDS. 2022; 17(6):333-337.

PMID: 36165078 PMC: 9530002. DOI: 10.1097/COH.0000000000000765.

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