Bioengineering Extracellular Vesicles for the Treatment of Cardiovascular Diseases

Overview

Journal Adv Biol (Weinh)

Specialties Biology
Biomedical Engineering
Biotechnology

Date 2022 Jul 2

PMID 35778828

Authors

Lalithasri Ramasubramanian

Shixian Du

Siraj Gidda

Nataliya Bahatyrevich

Dake Hao

Priyadarsini Kumar

Aijun Wang

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases (CVD) remain one of the leading causes of mortality worldwide. Despite recent advances in diagnosis and interventions, there is still a crucial need for new multifaceted therapeutics that can address the complicated pathophysiological mechanisms driving CVD. Extracellular vesicles (EVs) are nanovesicles that are secreted by all types of cells to transport molecular cargo and regulate intracellular communication. EVs represent a growing field of nanotheranostics that can be leveraged as diagnostic biomarkers for the early detection of CVD and as targeted drug delivery vesicles to promote cardiovascular repair and recovery. Though a promising tool for CVD therapy, the clinical application of EVs is limited by the inherent challenges in EV isolation, standardization, and delivery. Hence, this review will present the therapeutic potential of EVs and introduce bioengineering strategies that augment their natural functions in CVD.

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