Anti-dipeptidyl-peptidase-like Protein 6 Encephalitis with Pure Cerebellar Ataxia: a Case Report

Overview

Journal BMC Neurol

Publisher Biomed Central

Specialty Neurology

Date 2022 Jul 1

PMID 35778696

Authors

Jing Lin

Min Zhu

Xiaocheng Mao

Zeqing Jin

Meihong Zhou

Daojun Hong

Affiliations

Soon will be listed here.

Abstract

Background: Anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is a rare autoimmune encephalitis. The clinical symptoms of anti-DPPX encephalitis are often severe, manifested as diarrhea/weight loss, central nervous system hyperexcitability and cognitive dysfunction.

Case Presentation: An 18-year-old boy was admitted for 1-week-long cerebellar symptoms including dizziness, unsteady gait and frequent vomiting. Magnetic resonance imaging (MRI) displayed no abnormal findings. However, autoimmune encephalitis panel revealed anti-DPPX antibody was positive in the serum. This patient completely recovered after immunoglobulin and corticoids therapy. In addition, repeat serum antibody test for DPPX was negative within one month.

Conclusion: In addition to the classic triad, anti-DPPX encephalitis may manifest as mild and rare symptoms due to lower antibody titers. Fast identification of rare symptoms can help to quickly diagnosis and effective treatment.

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