History of Infertility and Long-term Weight, Body Composition, and Blood Pressure Among Women in Project Viva

Overview

Journal Ann Epidemiol

Publisher Elsevier

Specialty Public Health

Date 2022 Jul 1

PMID 35777630

Authors

Diana C Soria-Contreras

Emily Oken

Martha Maria Tellez-Rojo

Sheryl L Rifas-Shiman

Wei Perng

Jorge E Chavarro

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the association of a history of infertility with long-term weight, body composition, and blood pressure.

Methods: We studied 1581 women from the prospective cohort Project Viva. History of infertility was based on self-reported time to pregnancy ≥12 months or use of medical treatment to conceive for the index or any prior pregnancy; a diagnosis of infertility; claims for infertility treatments/prescriptions abstracted from medical records. The outcomes were weight, waist circumference, and body fat assessed through 12 years postpartum; and blood pressure assessed through 3 years postpartum. We used linear mixed-effect models adjusted for age, race/ethnicity, income, education, marital status, parity, and age at menarche.

Results: Three hundred forty-two women (21.6%) had a history of infertility. In adjusted models, women with versus without infertility, had higher average weight (3.29 kg, 95% confidence interval [CI]: 1.35-5.24), waist circumference (2.46 cm, 95% CI: 0.78-4.13) and body fat (1.76 kg, 95% CI: 0.09-3.43). Among younger (18-29 years), but not older (≥30 years) women, infertility was associated with higher systolic (4.08 mmHg, 95% CI: 0.93, 7.23) and diastolic blood pressure (2.16 mmHg, 95% CI: 0.11-4.20).

Conclusions: A history of infertility may serve as a marker to identify women at higher cardiometabolic risk.

Citing Articles

Cohort Profile Update: Project Viva mothers.

Rifas-Shiman S, Aris I, Switkowski K, Young J, Fleisch A, James-Todd T Int J Epidemiol. 2023; 52(6):e332-e339.

PMID: 37875013 PMC: 10749767. DOI: 10.1093/ije/dyad137.

Association of Early Pregnancy Perfluoroalkyl and Polyfluoroalkyl Substance Exposure With Birth Outcomes.

Zhang Y, Mustieles V, Sun Q, Coull B, McElrath T, Rifas-Shiman S JAMA Netw Open. 2023; 6(5):e2314934.

PMID: 37256622 PMC: 10233420. DOI: 10.1001/jamanetworkopen.2023.14934.

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