» Articles » PMID: 35774196

Gold Nanomaterials for Oral Cancer Diagnosis and Therapy: Advances, Challenges, and Prospects

Overview
Journal Mater Today Bio
Date 2022 Jul 1
PMID 35774196
Authors
Affiliations
Soon will be listed here.
Abstract

Early diagnosis and treatment of oral cancer are vital for patient survival. Since the oral cavity accommodates the second largest and most diverse microbiome community after the gut, the diagnostic and therapeutic approaches with low invasiveness and minimal damage to surrounding tissues are keys to preventing clinical intervention-related infections. Gold nanoparticles (AuNPs) are widely used in the research of cancer diagnosis and therapy due to their excellent properties such as surface-enhanced Raman spectroscopy, surface plasma resonance, controlled synthesis, the plasticity of surface morphology, biological safety, and stability. AuNPs had been used in oral cancer detection reagents, tumor-targeted therapy, photothermal therapy, photodynamic therapy, and other combination therapies for oral cancer. AuNPs-based noninvasive diagnosis and precise treatments further reduce the clinical intervention-related infections. This review is focused on the recent advances in research and application of AuNPs for early screening, diagnostic typing, drug delivery, photothermal therapy, radiotherapy sensitivity treatment, and combination therapy of oral cancer. Distinctive reports from the literature are summarized to highlight the latest advances in the development and application of AuNPs in oral cancer diagnosis and therapy. Finally, this review points out the challenges and prospects of possible applications of AuNPs in oral cancer diagnosis and therapy.

Citing Articles

Gold nanoparticles as innovative therapeutics for oral mucositis: A review of current evidence.

Choudhury M, Brunton P, Dias G, Schwass D, Meledandri C, Ratnayake J Drug Deliv Transl Res. 2024; .

PMID: 39625578 DOI: 10.1007/s13346-024-01748-x.


Molecular Targets of Plant-Derived Bioactive Compounds in Oral Squamous Cell Carcinoma.

Mitea G, Schroder V, Iancu I, Miresan H, Iancu V, Bucur L Cancers (Basel). 2024; 16(21).

PMID: 39518052 PMC: 11545343. DOI: 10.3390/cancers16213612.


The Integration of Gold Nanoparticles into Dental Biomaterials as a Novel Approach for Clinical Advancement: A Narrative Review.

Jongrungsomran S, Pissuwan D, Yavirach A, Rungsiyakull C, Rungsiyakull P J Funct Biomater. 2024; 15(10).

PMID: 39452589 PMC: 11508227. DOI: 10.3390/jfb15100291.


Recent advances in living cell nucleic acid probes based on nanomaterials for early cancer diagnosis.

Liu X, Shi Q, Qi P, Wang Z, Zhang T, Zhang S Asian J Pharm Sci. 2024; 19(3):100910.

PMID: 38948397 PMC: 11214190. DOI: 10.1016/j.ajps.2024.100910.


Nanomaterial Biosensors in Salivary Diagnosis of Oral Cancer: A Scoping Review.

Sethuraman S, Ramalingam K, Ramani P, M K Cureus. 2024; 16(5):e59779.

PMID: 38846178 PMC: 11154158. DOI: 10.7759/cureus.59779.


References
1.
Owosho A, Tsai C, Lee R, Freymiller H, Kadempour A, Varthis S . The prevalence and risk factors associated with osteoradionecrosis of the jaw in oral and oropharyngeal cancer patients treated with intensity-modulated radiation therapy (IMRT): The Memorial Sloan Kettering Cancer Center experience. Oral Oncol. 2016; 64:44-51. PMC: 5560021. DOI: 10.1016/j.oraloncology.2016.11.015. View

2.
Hu X, Zhang Y, Ding T, Liu J, Zhao H . Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities. Front Bioeng Biotechnol. 2020; 8:990. PMC: 7438450. DOI: 10.3389/fbioe.2020.00990. View

3.
Lei C, Kung H, Shih J . Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises. Int J Mol Sci. 2021; 22(9). PMC: 8124393. DOI: 10.3390/ijms22094903. View

4.
Du Z, Qi Y, He J, Zhong D, Zhou M . Recent advances in applications of nanoparticles in SERS in vivo imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020; 13(2):e1672. DOI: 10.1002/wnan.1672. View

5.
Xie J, Gong L, Zhu S, Yong Y, Gu Z, Zhao Y . Emerging Strategies of Nanomaterial-Mediated Tumor Radiosensitization. Adv Mater. 2018; 31(3):e1802244. DOI: 10.1002/adma.201802244. View