Genotypic Associations with Endostatin Levels and Clinical Features in Pulmonary Arterial Hypertension: a Quantitative Trait Association Study

Overview

Journal ERJ Open Res

Specialty Pulmonary Medicine

Date 2022 Jun 30

PMID 35769420

Authors

Catherine E Simpson

Megan Griffiths

Jun Yang

Melanie K Nies

Dhananjay Vaidya

Stephanie Brandal

Lisa J Martin

Michael W Pauciulo

Katie A Lutz

Anna W Coleman

Eric D Austin

D Dunbar Ivy

William C Nichols

Allen D Everett

Paul M Hassoun

Rachel L Damico

Affiliations

Soon will be listed here.

Abstract

https://bit.ly/3shXrNR.

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References

Damico R, Kolb T, Valera L, Wang L, Housten T, Tedford R . Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014; 191(2):208-18. PMC: 4347439. DOI: 10.1164/rccm.201409-1742OC. View

Zhu N, Pauciulo M, Welch C, Lutz K, Coleman A, Gonzaga-Jauregui C . Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension. Genome Med. 2019; 11(1):69. PMC: 6857288. DOI: 10.1186/s13073-019-0685-z. View

Taddei L, Chiarugi P, Brogelli L, Cirri P, Magnelli L, Raugei G . Inhibitory effect of full-length human endostatin on in vitro angiogenesis. Biochem Biophys Res Commun. 1999; 263(2):340-5. DOI: 10.1006/bbrc.1999.1342. View

Jansen R, Hottenga J, Nivard M, Abdellaoui A, Laport B, de Geus E . Conditional eQTL analysis reveals allelic heterogeneity of gene expression. Hum Mol Genet. 2017; 26(8):1444-1451. PMC: 6075455. DOI: 10.1093/hmg/ddx043. View

Simpson C, Griffiths M, Yang J, Nies M, Vaidya R, Brandal S . The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension. ERJ Open Res. 2021; 7(4. PMC: 8503279. DOI: 10.1183/23120541.00378-2021. View

Simpson C, Damico R, Hassoun P, Martin L, Yang J, Nies M . Noninvasive Prognostic Biomarkers for Left-Sided Heart Failure as Predictors of Survival in Pulmonary Arterial Hypertension. Chest. 2020; 157(6):1606-1616. PMC: 7268446. DOI: 10.1016/j.chest.2019.12.037. View

Vogel-Claussen J, Shehata M, Lossnitzer D, Skrok J, Singh S, Boyce D . Increased right ventricular Septomarginal trabeculation mass is a novel marker for pulmonary hypertension: comparison with ventricular mass index and right ventricular mass. Invest Radiol. 2011; 46(9):567-75. PMC: 3330237. DOI: 10.1097/RLI.0b013e31821b7041. View

Battle A, Khan Z, Wang S, Mitrano A, Ford M, Pritchard J . Genomic variation. Impact of regulatory variation from RNA to protein. Science. 2015; 347(6222):664-7. PMC: 4507520. DOI: 10.1126/science.1260793. View

OReilly M, Boehm T, Shing Y, Fukai N, Vasios G, Lane W . Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997; 88(2):277-85. DOI: 10.1016/s0092-8674(00)81848-6. View

10.

Daly C, Griffiths M, Simpson C, Yang J, Damico R, Vaidya R . Angiostatic Peptide, Endostatin, Predicts Severity in Pediatric Congenital Heart Disease-Associated Pulmonary Hypertension. J Am Heart Assoc. 2021; 10(20):e021409. PMC: 8751905. DOI: 10.1161/JAHA.120.021409. View

11.

Li J, Biggin M . Gene expression. Statistics requantitates the central dogma. Science. 2015; 347(6226):1066-7. DOI: 10.1126/science.aaa8332. View

12.

Slatkin M . Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. Nat Rev Genet. 2008; 9(6):477-85. PMC: 5124487. DOI: 10.1038/nrg2361. View

13.

Rhodes C, Otero-Nunez P, Wharton J, Swietlik E, Kariotis S, Harbaum L . Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome. Am J Respir Crit Care Med. 2020; 202(4):586-594. PMC: 7427383. DOI: 10.1164/rccm.202003-0510OC. View

14.

Rhodes C, Batai K, Bleda M, Haimel M, Southgate L, Germain M . Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2018; 7(3):227-238. PMC: 6391516. DOI: 10.1016/S2213-2600(18)30409-0. View

15.

Simpson C, Chen J, Damico R, Hassoun P, Martin L, Yang J . Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension. Eur Respir J. 2020; 55(4). PMC: 8243361. DOI: 10.1183/13993003.01761-2019. View

16.

Wu X, Wu J, Xin Z, Wang H, Zhu X, Pan L . A 3' UTR SNP in COL18A1 is associated with susceptibility to HBV related hepatocellular carcinoma in Chinese: three independent case-control studies. PLoS One. 2012; 7(3):e33855. PMC: 3312886. DOI: 10.1371/journal.pone.0033855. View

17.

Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J . A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension. J Mol Med (Berl). 2013; 91(11):1315-27. DOI: 10.1007/s00109-013-1059-4. View

18.

Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D . PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007; 81(3):559-75. PMC: 1950838. DOI: 10.1086/519795. View