Relationship Between Prevalence and Risk of Osteoporosis or Osteoporotic Fracture with Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2022 Jun 28

PMID 35764892

Authors

Binjing Pan

Jing Cai

Pingping Zhao

Jingfang Liu

Songbo Fu

Gaojing Jing

Qianglong Niu

Qiong Li

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this meta-analysis was to investigate the relationship between prevalence and risks of osteoporosis or osteoporotic fracture and non-alcoholic fatty liver disease (NAFLD).

Methods: Five databases, including PubMed, Web of Science, Embase, Scopus and Cochrane Library, were searched since the conception of these databases until December 2021. The cohort studies, cross-sectional analyses or case-control studies evaluating the relationship between osteoporosis or osteoporotic fracture and NAFLD were retrieved from these databases. Relevant data were extracted from the included studies, and a meta-analysis was performed.

Results: A total of seven studies were included. The prevalence of osteoporosis or osteoporotic fractures was higher in the NAFLD group than in the non-NAFLD group [OR = 1.17, 95%CI(1.04,1.31)], while the prevalence of osteoporosis was higher in the NAFLD group than in the non-NAFLD group [OR = 1.46, 95%CI (1.21,1.77) and OR = 1.48, 95%CI (1.31,1.68), respectively] in men and women. The risk of osteoporosis or osteoporotic fractures was higher in the NAFLD group than in the non-NAFLD group [OR = 1.33,95%CI (1.24,1.44) and OR = 1.57,95%CI (1.08,2.29), respectively]. The risk of osteoporosis or osteoporotic fractures was higher in male and female NAFLD groups than that in the non-NAFLD group [OR = 1.29, 95%CI(1.14,1.47) and OR = 1.36, 95%CI (1.25,1.48), respectively]. After parameter adjustment, the risk of osteoporosis or osteoporotic fracture was higher in the male NAFLD group than in the non-NAFLD group [OR = 2.10, 95%CI(1.36,3.25)], while no significant difference was found among women [OR = 1.13, 95%CI (0.86,1.48)].

Conclusions: The prevalence and risk of osteoporosis or osteoporotic fractures were significantly associated with NAFLD in men and women.

Trial Registration: PROSPERO 2022 CRD42022304708.

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