[Research Advances on the Characteristics of Fibroblast in Keloid]

Overview

Journal Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi

Date 2022 Jun 28

PMID 35764588

Authors

Y Z Wang

C Su

S Q Fu

L Q Liu

Affiliations

Soon will be listed here.

Abstract

In re-cent 20 years, the development of cell biology technology has promoted the research of keloid. Keloid fibroblasts (KFbs) are the main effector cells in keloid, which are closely related to the occurrence and development of keloid. It is significantly different in terms of biological characteristics and gene expression between KFbs and normal fibroblasts. This articles reviews the characteristics of KFbs from multiple perspectives, describing its biological character- istics in details including microstructures, metabolic character- istics, and proliferation properties, and introducing the main characteristics of heterogeneity and genomics of KFbs. The further research on KFbs will help to elucidate the pathogenesis of keloids and provide valuable strategies for the prevention and treatment of keloids.

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