An Update on the Measurement of Motor Cerebellar Dysfunction in Multiple Sclerosis

Overview

Journal Cerebellum

Publisher Springer

Specialty Neurology

Date 2022 Jun 27

PMID 35761144

Authors

Katherine Hope Kenyon

Frederique Boonstra

Gustavo Noffs

Helmut Butzkueven

Adam P Vogel

Scott Kolbe

Anneke van der Walt

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is a progressive disease that often affects the cerebellum. It is characterised by demyelination, inflammation, and neurodegeneration within the central nervous system. Damage to the cerebellum in MS is associated with increased disability and decreased quality of life. Symptoms include gait and balance problems, motor speech disorder, upper limb dysfunction, and oculomotor difficulties. Monitoring symptoms is crucial for effective management of MS. A combination of clinical, neuroimaging, and task-based measures is generally used to diagnose and monitor MS. This paper reviews the present and new tools used by clinicians and researchers to assess cerebellar impairment in people with MS (pwMS). It also describes recent advances in digital and home-based monitoring for people with MS.

Citing Articles

Microstructural Alterations of Cerebellar Peduncles in Relapsing Remitting Multiple Sclerosis: a Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.

Lomer N, Saberi A, AmirAshjei Asalemi K, Sarlak K Cerebellum. 2024; 24(1):10.

PMID: 39661205 DOI: 10.1007/s12311-024-01764-0.

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