Natural Bioactive Compounds of Spp. for Therapeutic and Nutraceutical Supplements

Overview

Journal Front Plant Sci

Date 2022 Jun 27

PMID 35756862

Authors

Maria Isabel Iniguez-Luna

Jorge Cadena-Iniguez

Ramon Marcos Soto-Hernandez

Francisco Javier Morales-Flores

Moises Cortes-Cruz

Kazuo N Watanabe

Affiliations

Soon will be listed here.

Abstract

Natural products are in great demand because certain secondary metabolites (SMs) are sources of antioxidants, flavorings, active substances, or anticancer agents with less aggressiveness and selectivity, among which triterpenes and flavonoids are of importance because they inhibit carcinogenesis. For spp. P. Br. (chayotes), there is scientific evidence of antiproliferative activity that has occurred when cancer cell lines have been treated with this fruit. In order to compare future therapeutic designs and identify new and ancestral characteristics, triterpenes and flavonoids were determined in contrasting genotypes. The obtained data were analyzed a cladistics approach, with the aim of identifying the characteristics and state of phytochemicals and genetic variables. The concentrations of flavonoids and triterpenes were determined, and a more complex composition of secondary metabolites was found in the wild types as compared to their domesticated genotypes. Bitter fruits contained a higher number of SMs, followed by those with a neutral and sweet flavor. A cladogram showed the differentiation of the three groups based on the flavor of the fruits. The diversity of SMs decreases in evolutionary terms, in response to domestication and environmental adaptation. Therefore, genotypes can be feasibly selected based on fruit flavor for gross-breeding, and cytotoxicity can be reduced without losing possible therapeutic effects.

Citing Articles

Genotypes of spp. as a Source of Natural Products with Biological Activity.

Cadena-Iniguez J, Arevalo-Galarza M, Santiago-Osorio E, Aguiniga-Sanchez I, Cadena-Zamudio J, Soto-Hernandez M Life (Basel). 2025; 15(1).

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Li-Fraumeni Syndrome: Narrative Review Through a Case Report with Ten Years of Primary Tumor Remission Associated with H387 07 Supplementation.

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Antioxidant and Anti-Inflammatory Effect of the Consumption of Powdered Concentrate of var. in Mexican Older Adults with Metabolic Syndrome.

Arista-Ugalde T, Santiago-Osorio E, Monroy-Garcia A, Rosado-Perez J, Aguiniga-Sanchez I, Cadena-Iniguez J Antioxidants (Basel). 2022; 11(6).

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Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus.

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