Zika a Vector Borne Disease Detected in Newer States of India Amidst the COVID-19 Pandemic

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2022 Jun 27

PMID 35756041

Authors

Pragya D Yadav

Harmanmeet Kaur

Nivedita Gupta

Rima R Sahay

Gajanan N Sapkal

Anita M Shete

Gururaj R Deshpande

Sreelekshmy Mohandas

Triparna Majumdar

Savita Patil

Priyanka Pandit

Abhinendra Kumar

Dimpal A Nyayanit

K H Sreelatha

S Manjusree

Hiba Sami

Haris Mazoor Khan

Anuradha Malhotra

Kanwardeep Dhingra

Ravisekhar Gadepalli

V Sudha Rani

Manoj Kumar Singh

Yash Joshi

Manisha Dudhmal

Nandini Duggal

Mala Chabbra

Lalit Dar

Pranita Gawande

Jyoti Yemul

Kaumudi Kalele

Rajalakshmi Arjun

K Nagamani

Biswa Borkakoty

Ganesh Sahoo

Ira Praharaj

Shanta Dutta

Pradip Barde

S C Jaryal

Vinita Rawat

Affiliations

Soon will be listed here.

Abstract

Background: During the second wave of the COVID-19 pandemic, outbreaks of Zika were reported from Kerala, Uttar Pradesh, and Maharashtra, India in 2021. The Dengue and Chikungunya negative samples were retrospectively screened to determine the presence of the Zika virus from different geographical regions of India.

Methods: During May to October 2021, the clinical samples of 1475 patients, across 13 states and a union territory of India were screened and re-tested for Dengue, Chikungunya and Zika by CDC Trioplex Real time RT-PCR. The Zika rRTPCR positive samples were further screened with anti-Zika IgM and Plaque Reduction Neutralization Test. Next generation sequencing was used for further molecular characterization.

Results: The positivity was observed for Zika (67), Dengue (121), and Chikungunya (10) amongst screened cases. The co-infections of Dengue/Chikungunya, Dengue/Zika, and Dengue/Chikungunya/Zika were also observed. All Zika cases were symptomatic with fever (84%) and rash (78%) as major presenting symptoms. Of them, four patients had respiratory distress, one presented with seizures, and one with suspected microcephaly at birth. The Asian Lineage of Zika and all four serotypes of Dengue were found in circulation.

Conclusion: Our study indicates the spread of the Zika virus to several states of India and an urgent need to strengthen its surveillance.

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