Role of the Endothelium in Neonatal Diseases

Overview

Journal Newborn (Clarksville)

Date 2022 Jun 27

PMID 35754998

Authors

Olachi J Mezu-Ndubuisi

Akhil Maheshwari

Affiliations

Soon will be listed here.

Abstract

In both fetal and neonatal physiologic and pathologic processes in most organs, endothelial cells are known to play critical roles. Although the endothelium is one of the most ubiquitous cell type in the body, the tight adherence to the blood vessel wall has made it difficult to study their diverse function and structure. In this article, we have reviewed endothelial cell origins and explored their heterogeneity in terms of structure, function, developmental changes, and their role in inflammatory and infectious diseases. We have also attempted to evaluate the untapped therapeutic potentials of endothelial cells in neonatal disease. This article comprises various peer-reviewed studies, including ours, and an extensive database literature search from EMBASE, PubMed, and Scopus.

Citing Articles

L-Citrulline in Neonates: From Bench to Bed Side.

Mascarenhas D, Mohammadi A, Higazy R, Ivanovska J, Gauda E, Jasani B Children (Basel). 2025; 12(1).

PMID: 39857873 PMC: 11763423. DOI: 10.3390/children12010042.

Novel Small Molecules with Anti-Inflammatory and Anti-Angiogenic Activity in a Mouse Model of Oxygen-Induced Retinopathy.

Dayoub A, Acharya E, Dibas A, Jones H, Acharya S Cells. 2024; 13(16).

PMID: 39195259 PMC: 11353024. DOI: 10.3390/cells13161371.

Editorial: Endotyping and phenotyping prematurity and its complications.

Pierro M, Philip R, Renesme L, Villamor E Front Pediatr. 2023; 11:1217530.

PMID: 37346894 PMC: 10280727. DOI: 10.3389/fped.2023.1217530.

References

Kissa K, Herbomel P . Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature. 2010; 464(7285):112-5. DOI: 10.1038/nature08761. View

Bonauer A, Boon R, Dimmeler S . Vascular microRNAs. Curr Drug Targets. 2010; 11(8):943-9. DOI: 10.2174/138945010791591313. View

Lobov I, Brooks P, Lang R . Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A. 2002; 99(17):11205-10. PMC: 123234. DOI: 10.1073/pnas.172161899. View

Du X, Hu N, Yu H, Hong L, Ran F, Huang D . miR-150 regulates endothelial progenitor cell differentiation via Akt and promotes thrombus resolution. Stem Cell Res Ther. 2020; 11(1):354. PMC: 7425584. DOI: 10.1186/s13287-020-01871-9. View

Malek A, Izumo S . Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress. J Cell Sci. 1996; 109 ( Pt 4):713-26. DOI: 10.1242/jcs.109.4.713. View

Drake C, Fleming P . Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood. 2000; 95(5):1671-9. View

Petri B, Bixel M . Molecular events during leukocyte diapedesis. FEBS J. 2006; 273(19):4399-407. DOI: 10.1111/j.1742-4658.2006.05439.x. View

Cleuren A, van der Ent M, Jiang H, Hunker K, Yee A, Siemieniak D . The in vivo endothelial cell translatome is highly heterogeneous across vascular beds. Proc Natl Acad Sci U S A. 2019; 116(47):23618-23624. PMC: 6876253. DOI: 10.1073/pnas.1912409116. View

Nussbaum C, Sperandio M . Innate immune cell recruitment in the fetus and neonate. J Reprod Immunol. 2011; 90(1):74-81. DOI: 10.1016/j.jri.2011.01.022. View

10.

Niethamer T, Stabler C, Leach J, Zepp J, Morley M, Babu A . Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury. Elife. 2020; 9. PMC: 7176435. DOI: 10.7554/eLife.53072. View

11.

Bussolino F, Camussi G, Tetta C, Garbarino G, Bosia A, Baglioni C . Selected cytokines promote the synthesis of platelet-activating factor in vascular endothelial cells: comparison between tumor necrosis factor alpha and beta and interleukin-1. J Lipid Mediat. 1990; 2 Suppl:S15-22. View

12.

Dejana E, Orsenigo F, Lampugnani M . The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci. 2008; 121(Pt 13):2115-22. DOI: 10.1242/jcs.017897. View

13.

Stahl A, Connor K, Sapieha P, Chen J, Dennison R, Krah N . The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010; 51(6):2813-26. PMC: 2891451. DOI: 10.1167/iovs.10-5176. View

14.

Risau W, Flamme I . Vasculogenesis. Annu Rev Cell Dev Biol. 1995; 11:73-91. DOI: 10.1146/annurev.cb.11.110195.000445. View

15.

Jakobsson L, Franco C, Bentley K, Collins R, Ponsioen B, Aspalter I . Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol. 2010; 12(10):943-53. DOI: 10.1038/ncb2103. View

16.

Khan S, Solomon M, McCoy Jr J . Detection of circulating endothelial cells and endothelial progenitor cells by flow cytometry. Cytometry B Clin Cytom. 2005; 64(1):1-8. DOI: 10.1002/cyto.b.20040. View

17.

Bazzoni G, Martinez Estrada O, Dejana E . Molecular structure and functional role of vascular tight junctions. Trends Cardiovasc Med. 2000; 9(6):147-52. DOI: 10.1016/s1050-1738(99)00022-5. View

18.

Bhatt A, Pryhuber G, Huyck H, Watkins R, Metlay L, Maniscalco W . Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001; 164(10 Pt 1):1971-80. DOI: 10.1164/ajrccm.164.10.2101140. View

19.

Dagher F, Pollina R, Rogers D, Gennaro M, Ascer E . The value and limitations of L-arginine infusion on glomerular and tubular function in the ischemic/reperfused kidney. J Vasc Surg. 1995; 21(3):453-8; discussion 458-9. DOI: 10.1016/s0741-5214(95)70287-3. View

20.

Potente M, Gerhardt H, Carmeliet P . Basic and therapeutic aspects of angiogenesis. Cell. 2011; 146(6):873-87. DOI: 10.1016/j.cell.2011.08.039. View