Emergence of - and (A)-Producing Isolated from Hospital Sewage

Overview

Journal Infect Drug Resist

Publisher Dove Medical Press

Date 2022 Jun 27

PMID 35754787

Authors

Haishan Mo

Xu Lin

Ming Liu

Hui Liang

Affiliations

Soon will be listed here.

Abstract

Cephalosporins and azithromycin are clinical antibiotics used to treat infections. Co-resistance to cephalosporins and azithromycin has been observed in some , but it has only rarely been reported in species. In this study, we isolated a cephalosporin- and azithromycin-resistant strain, VFN3, from hospital sewage. Whole-genome sequencing results showed that the strain VFN3 possesses an IncA/C2 plasmid, pVFN3-blaOXA-193K. This conjugative plasmid carries several clinically relevant drug resistance genes, including (A) and . We also found that in the strain VFN3, (A) and are surrounded by insertion sequences and class I integrons, respectively. These data suggest that mobile elements mediate the transfer of (A) and . This is the first reported species that possesses an (A)- and -bearing conjugative plasmid. The emergence of this conjugative multi-drug-resistance plasmid is of great concern to public health.

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