Antihypertensive Drugs and Risk of Bone Fractures

Overview

Journal Drugs Aging

Specialties Geriatrics
Pharmacology

Date 2022 Jun 26

PMID 35754069

Authors

Maria Velliou

Elias Sanidas

Aliki Zografou

Dimitrios Papadopoulos

Nikolaos Dalianis

John Barbetseas

Affiliations

Soon will be listed here.

Abstract

Antihypertensive drugs are among the most documented regimens worldwide with an overall survival and cardioprotective benefit. However, there is evidence that they cause symptoms of orthostatic hypotension (i.e., dizziness and syncope) placing patients at risk for falls and fall-related injuries such as bone fractures. Moreover, it seems that they might impact bone metabolism and architecture impairing bone health. The aim of this review was to summarize the accumulative literature exploring any potential association between several antihypertensive medications including diuretics, renin-angiotensin-aldosterone system inhibitors, beta-blockers and calcium channel blockers and the risk of fractures.

Citing Articles

Association of diuretics with falls and wrist fractures: a Mendelian randomization study.

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Effect of salt substitution on fracture-a secondary analysis of the Salt Substitute and Stroke Study (SSaSS).

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