Relationship Between Osteopontin and Bone Mineral Density

Overview

Journal Acta Endocrinol (Buchar)

Specialty Endocrinology

Date 2022 Jun 24

PMID 35747863

Authors

A Vancea

O Serban

D Fodor

Affiliations

Soon will be listed here.

Abstract

Recent studies suggest that osteopontin (OPN) could be used as an early marker for the diagnosis of bone disorders. Considering the contradictory opinions in the literature, the objective of this systematic review is to analyse the current information regarding the relationship between OPN and bone mineral density (BMD), which represents an important process in the development of osteoporosis. We performed a literature search of clinical trials using the PubMed database, published between 1999-2020, and identified 7 studies that were eligible for analysis. The eligibility criteria were based on studies that analysed the relationship between osteopontin and bone mineral density on human subjects. Conclusion: serum OPN levels might be used as a biomarker of the early diagnosis of osteoporosis in postmenopausal women, with or without osteoporotic vertebral fractures.

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References

Denhardt D, Giachelli C, Rittling S . Role of osteopontin in cellular signaling and toxicant injury. Annu Rev Pharmacol Toxicol. 2001; 41:723-49. DOI: 10.1146/annurev.pharmtox.41.1.723. View

Cho E, Cho K, Lee H, Kim S . High serum osteopontin levels are associated with low bone mineral density in postmenopausal women. J Korean Med Sci. 2013; 28(10):1496-9. PMC: 3792605. DOI: 10.3346/jkms.2013.28.10.1496. View

Tsao Y, Huang Y, Wu H, Liu Y, Liu Y, Lee O . Osteocalcin Mediates Biomineralization during Osteogenic Maturation in Human Mesenchymal Stromal Cells. Int J Mol Sci. 2017; 18(1). PMC: 5297792. DOI: 10.3390/ijms18010159. View

Monda M, Messina G, Mangoni C, De Luca B . Resting energy expenditure and fat-free mass do not decline during aging in severely obese women. Clin Nutr. 2008; 27(4):657-9. DOI: 10.1016/j.clnu.2008.04.005. View

Shapses S, Pop L, Wang Y . Obesity is a concern for bone health with aging. Nutr Res. 2017; 39:1-13. PMC: 5385856. DOI: 10.1016/j.nutres.2016.12.010. View

Rozman C, Feliu E, Berga L, Reverter J, Climent C, Ferran M . Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Exp Hematol. 1989; 17(1):34-7. View

Hadjidakis D, Androulakis I . Bone remodeling. Ann N Y Acad Sci. 2007; 1092:385-96. DOI: 10.1196/annals.1365.035. View

Herzog R, Alvarez-Pasquin M, Diaz C, Del Barrio J, Estrada J, Gil A . Are healthcare workers' intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review. BMC Public Health. 2013; 13:154. PMC: 3602084. DOI: 10.1186/1471-2458-13-154. View

Wei Q, Huang L, Tan X, Chen Z, Chen S, Deng W . Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women. Scand J Clin Lab Invest. 2015; 76(1):33-9. DOI: 10.3109/00365513.2015.1087045. View

10.

Chellaiah M, Hruska K . The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif Tissue Int. 2002; 72(3):197-205. DOI: 10.1007/s00223-002-1025-6. View

11.

Meunier P, Aaron J, Edouard C, Vignon G . Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res. 1971; 80:147-54. DOI: 10.1097/00003086-197110000-00021. View

12.

Chiang T, Chang I, Lee H, Lee H, Huang C, Cheng Y . Osteopontin regulates anabolic effect in human menopausal osteoporosis with intermittent parathyroid hormone treatment. Osteoporos Int. 2010; 22(2):577-85. DOI: 10.1007/s00198-010-1327-x. View

13.

Vasikaran S, Glendenning P, Morris H . The role of biochemical markers of bone turnover in osteoporosis management in clinical practice. Clin Biochem Rev. 2007; 27(3):119-21. PMC: 1579290. View

14.

Vasikaran S, Eastell R, Bruyere O, Foldes A, Garnero P, Griesmacher A . Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2010; 22(2):391-420. DOI: 10.1007/s00198-010-1501-1. View

15.

Fodor D, Bondor C, Albu A, Simon S, Craciun A, Muntean L . The value of osteopontin in the assessment of bone mineral density status in postmenopausal women. J Investig Med. 2012; 61(1):15-21. DOI: 10.2310/JIM.0b013e3182761264. View

16.

Zhang B, Dai J, Wang H, Wei H, Zhao J, Guo Y . Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis. Biochem Biophys Res Commun. 2014; 452(3):795-800. DOI: 10.1016/j.bbrc.2014.08.149. View

17.

Messina G, Vicidomini C, Viggiano A, Tafuri D, Cozza V, Cibelli G . Enhanced parasympathetic activity of sportive women is paradoxically associated to enhanced resting energy expenditure. Auton Neurosci. 2012; 169(2):102-6. DOI: 10.1016/j.autneu.2012.05.003. View

18.

Tarquini C, Mattera R, Mastrangeli F, Agostinelli S, Ferlosio A, Bei R . Comparison of tissue transglutaminase 2 and bone biological markers osteocalcin, osteopontin and sclerostin expression in human osteoporosis and osteoarthritis. Amino Acids. 2016; 49(3):683-693. DOI: 10.1007/s00726-016-2290-4. View

19.

Yoshitake H, Rittling S, Denhardt D, Noda M . Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci U S A. 1999; 96(14):8156-60. PMC: 22204. DOI: 10.1073/pnas.96.14.8156. View

20.

Sarkar S, Mitlak B, Wong M, Stock J, Black D, Harper K . Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res. 2002; 17(1):1-10. DOI: 10.1359/jbmr.2002.17.1.1. View