Relationship of Placental and Serum Lipoprotein-Associated Phospholipase A2 Levels with Hypertensive Disorders of Pregnancy

Overview

Journal Int J Womens Health

Publisher Dove Medical Press

Specialty Gynecology & Obstetrics

Date 2022 Jun 24

PMID 35747524

Authors

Jing Wang

Xing Dong

Hong-Yan Wu

Wen-Hua Bu

Rong Cong

Xin Wang

Li-Xin Shang

Wen Jiang

Affiliations

Soon will be listed here.

Abstract

Background: A series of studies has shown that lipoprotein-associated phospholipase A2 (Lp-PLA2) is closely associated with abnormal lipid metabolism and vascular endothelial cell injury, but its role in hypertensive disorders of pregnancy (HDP) remains unclear. This study aims to determine the relationship between placental and serum LP-PLA2 levels and HDP, and to provide a feasible method for predicting HDP.

Methods: The placental and serum Lp-PLA2 levels of 63 patients with HDP (20, 25, and 18 cases with gestational hypertension, mild preeclampsia, and severe preeclampsia, respectively) and 20 women with normal pregnancies (control group) were measured via a combination of tissue microarray and immunohistochemistry, real-time quantitative RT-PCR and enzyme-linked immunosorbent assay (ELISA).

Results: 1) The gene and protein expression levels of placental LP-PLA2: the HDP group had significantly higher levels than those of the control group (P < 0.05). The mild preeclampsia group had significantly higher levels than those of the control group (P < 0.05); the severe preeclampsia group had significantly higher levels than those of the mild preeclampsia group (P < 0.05). 2) Serum levels of Lp-PLA2: the HDP group had significantly higher levels than those of the control group (P < 0.05). The Lp-PLA2 levels increased gradually with the progression of the HDP; there were significant differences in the four groups using pair-wise comparisons (P < 0.05). 3) Serum levels of LP-PLA2 were positively correlated with placental LP-PLA2 levels in the HDP group (r = 0.435, P < 0.05).

Conclusion: Elevated Lp-PLA2 levels may be associated with the occurrence of HDP, and changes of Lp-PLA2 levels in the maternal blood may be regarded as a monitoring indicator for this disease.

Citing Articles

Pregnancy Metabolic Adaptation and Changes in Placental Metabolism in Preeclampsia.

Li Y, Ma L, He R, Teng F, Qin X, Liang X Geburtshilfe Frauenheilkd. 2024; 84(11):1033-1042.

PMID: 39524034 PMC: 11543110. DOI: 10.1055/a-2403-4855.

References

Siddiqui M, Kennedy G, Carr F, Doney A, Pearson E, Morris A . Lp-PLA activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study. Diabetologia. 2018; 61(6):1344-1353. PMC: 6447502. DOI: 10.1007/s00125-018-4601-7. View

Otsuka F, Zhao X, Trout H, Qiao Y, Wasserman B, Nakano M . Community-based statins and advanced carotid plaque: Role of CD163 positive macrophages in lipoprotein-associated phospholipase A activity in atherosclerotic plaque. Atherosclerosis. 2017; 267:78-89. DOI: 10.1016/j.atherosclerosis.2017.10.014. View

Jia K, Ma L, Wu S, Yang W . Serum Levels of Complement Factors C1q, Bb, and H in Normal Pregnancy and Severe Pre-Eclampsia. Med Sci Monit. 2019; 25:7087-7093. PMC: 6767947. DOI: 10.12659/MSM.915777. View

Ekmekci O, Ekmekci H, Gungor Z, Tuten A, Toprak M, Korkmaz M . Evaluation of Lp-PLA2 mass, vitronectin and PAI-1 activity levels in patients with preeclampsia. Arch Gynecol Obstet. 2014; 292(1):53-8. DOI: 10.1007/s00404-014-3601-1. View

Tenorio M, Ferreira R, Moura F, Bueno N, de Oliveira A, Goulart M . Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia. Oxid Med Cell Longev. 2019; 2019:8238727. PMC: 6875353. DOI: 10.1155/2019/8238727. View

Passaro A, Vigna G, Romani A, Sanz J, Cavicchio C, Bonaccorsi G . Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes. Oxid Med Cell Longev. 2018; 2018:1752940. PMC: 6247389. DOI: 10.1155/2018/1752940. View

Tian Y, Jia H, Li S, Wu Y, Guo L, Tan G . The associations of stroke, transient ischemic attack, and/or stroke-related recurrent vascular events with Lipoprotein-associated phospholipase A2: A systematic review and meta-analysis. Medicine (Baltimore). 2018; 96(51):e9413. PMC: 5758266. DOI: 10.1097/MD.0000000000009413. View

Paik J, Kim M, Kim M, Yen Y, Ahn H, Lee S . Circulating Lp-PLA₂ activity correlates with oxidative stress and cytokines in overweight/obese postmenopausal women not using hormone replacement therapy. Age (Dordr). 2015; 37(2):32. PMC: 4385327. DOI: 10.1007/s11357-015-9770-4. View

Cao J, Hsu Y, Li S, Woods Jr V, Dennis E . Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry. J Lipid Res. 2012; 54(1):127-33. PMC: 3520519. DOI: 10.1194/jlr.M030221. View

10.

He S, Chousterman B, Fenn A, Anzai A, Nairz M, Brandt M . Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages. Circ Heart Fail. 2015; 8(5):980-7. PMC: 4568849. DOI: 10.1161/CIRCHEARTFAILURE.115.002334. View

11.

Li J, Wang H, Tian J, Chen B, Du F . Change in lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndrome. Medicine (Baltimore). 2018; 97(28):e11517. PMC: 6076090. DOI: 10.1097/MD.0000000000011517. View

12.

Yan D, Li D, Yang Y, Xia J, Wang X, Zhou C . Ubiquitin D is correlated with colon cancer progression and predicts recurrence for stage II-III disease after curative surgery. Br J Cancer. 2010; 103(7):961-9. PMC: 2965875. DOI: 10.1038/sj.bjc.6605870. View

13.

Zhang Y, Zhang M, Yu F, Lu S, Sun H, Tang H . Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer. J Exp Clin Cancer Res. 2015; 34:145. PMC: 4665890. DOI: 10.1186/s13046-015-0261-3. View

14.

Chen B, Deng Y, Xu X, Ma S, Tang L, Chen J . Effect of Selective Thrombus Aspiration on Serum Lipoprotein-Associated Phospholipase A2 in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention with High Thrombus Burden. Acta Cardiol Sin. 2018; 34(3):233-241. PMC: 5968339. DOI: 10.6515/ACS.201805_34(3).20170227A. View

15.

Alahakoon T, Medbury H, Williams H, Lee V . Lipid profiling in maternal and fetal circulations in preeclampsia and fetal growth restriction-a prospective case control observational study. BMC Pregnancy Childbirth. 2020; 20(1):61. PMC: 6993402. DOI: 10.1186/s12884-020-2753-1. View

16.

Tomimatsu T, Mimura K, Matsuzaki S, Endo M, Kumasawa K, Kimura T . Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors. Int J Mol Sci. 2019; 20(17). PMC: 6747625. DOI: 10.3390/ijms20174246. View

17.

Tarca A, Romero R, Benshalom-Tirosh N, Than N, Gudicha D, Done B . The prediction of early preeclampsia: Results from a longitudinal proteomics study. PLoS One. 2019; 14(6):e0217273. PMC: 6548389. DOI: 10.1371/journal.pone.0217273. View

18.

Jackisch L, Kumsaiyai W, Moore J, Al-Daghri N, Kyrou I, Barber T . Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids. Diabetologia. 2018; 61(5):1155-1166. PMC: 6449000. DOI: 10.1007/s00125-018-4558-6. View

19.

Dhamoon M, Cheung Y, Moon Y, Wright C, Sacco R, Elkind M . Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. PLoS One. 2019; 14(4):e0214784. PMC: 6443177. DOI: 10.1371/journal.pone.0214784. View

20.

Huang F, Wang K, Shen J . Lipoprotein-associated phospholipase A2: The story continues. Med Res Rev. 2019; 40(1):79-134. PMC: 6973114. DOI: 10.1002/med.21597. View