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Proton MR Spectroscopy of Pediatric Brain Disorders

Overview
Specialty Radiology
Date 2022 Jun 24
PMID 35741272
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Abstract

In vivo MR spectroscopy is a non -invasive methodology that provides information about the biochemistry of tissues. It is available as a "push-button" application on state-of-the-art clinical MR scanners. MR spectroscopy has been used to study various brain diseases including tumors, stroke, trauma, degenerative disorders, epilepsy/seizures, inborn errors, neuropsychiatric disorders, and others. The purpose of this review is to provide an overview of MR spectroscopy findings in the pediatric population and its clinical use.

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References
1.
Aida N . H-MR Spectroscopy of the Early Developmental Brain, Neonatal Encephalopathies, and Neurometabolic Disorders. Magn Reson Med Sci. 2021; 21(1):9-28. PMC: 9199977. DOI: 10.2463/mrms.rev.2021-0055. View

2.
Burri R, Steffen C, HERSCHKOWITZ N . N-acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development. Dev Neurosci. 1991; 13(6):403-11. DOI: 10.1159/000112191. View

3.
Bluml S, Wisnowski J, Nelson Jr M, Paquette L, Panigrahy A . Metabolic maturation of white matter is altered in preterm infants. PLoS One. 2014; 9(1):e85829. PMC: 3899075. DOI: 10.1371/journal.pone.0085829. View

4.
Thurston J, Sherman W, Hauhart R, Kloepper R . myo-inositol: a newly identified nonnitrogenous osmoregulatory molecule in mammalian brain. Pediatr Res. 1989; 26(5):482-5. DOI: 10.1203/00006450-198911000-00024. View

5.
Seymour K, Bluml S, Sutherling J, Sutherling W, Ross B . Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet. MAGMA. 1999; 8(1):33-42. DOI: 10.1007/BF02590633. View